Post Helicobacter pylori Gastric Diseases
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A variety of researches have been focused on Helicobacter pylori (H. pylori) in gastroenterological field, and H. pylori has been recognized as etiologically responsible for gastritis-associated peptic ulcers and the majority of gastric cancers. The incidence rate of H. pylori infection is higher in Asian countries including Japan than in Western countries. However, past natural circumstances in Japan suitable for an inhabiting of H. pylori have been improved in parallel with the sanitary developments. In addition, the eradication therapy has been permitted with national insurance to most patients with H. pylori infection in 2013. As a result, the present infection rate is gradually decreasing. Based on the above surrounding environment, an age-depending decrease in acid secretion due to mucosal atrophy caused by chronic H. pylori infection is recently lacking. Therefore, certain acid secretion is continuously maintained with no age relationship. Accordingly, most Japanese physicians must switch their focus to the acid-related diseases (H. pylori-non-associated diseases) from the H. pylori-associated diseases throughout the entire generations.
As post H. pylori gastric diseases, this part will give the information about (1) H. pylori-negative mucosal injury excluding gastric cancer because it is introduced in the next chapter, (2) functional dyspepsia whose pathophysiology is in part associated with mucosal sensitivity to acid exposure, and (3) association of non-alcoholic fatty liver disease with gastroesophageal diseases.
KeywordsAcid secretion Chemical sensitivity Functional disorders Metabolic syndrome
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