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Heart Genomics pp 281–292Cite as

Progress of Epigenetic Changes in Heart Failure

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Part of the book series: Translational Bioinformatics ((TRBIO,volume 16))

Abstract

Cardiac function requires sophisticated regulatory networks to orchestrate environmental adaptation. These regulatory networks in heart remodeling to maintain its function are composed of transcriptional control and signaling systems. Epigenetic processes play vital roles in the process. These include DNA and histone modification and classes of regulatory RNAs, such as microRNAs and long noncoding RNAs. Here, we review this emerging landscape to summarize their functions and roles in cardiac remodeling and to assist in exploring this previously hidden layer of gene regulation that may underpin heart adaptation in remodeling.

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Authors and Affiliations

  1. Shanghai Institute of Cardiovascular Diseases, Clinical Science Institute, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, China

    Peng Yu & Hong Jiang

  2. Department of General Practice, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, China

    Ming Liu

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  1. Peng Yu
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  2. Ming Liu
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  3. Hong Jiang
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Correspondence to Hong Jiang .

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Editors and Affiliations

  1. Zhongshan Hospital, Fudan University, Shanghai, China

    Hong Jiang

  2. Zhongshan Hospital, Fudan University, Shanghai, China

    Ming Liu

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Yu, P., Liu, M., Jiang, H. (2018). Progress of Epigenetic Changes in Heart Failure. In: Jiang, H., Liu, M. (eds) Heart Genomics. Translational Bioinformatics, vol 16. Springer, Singapore. https://doi.org/10.1007/978-981-13-1429-2_10

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