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Circular RNAs in Organ Fibrosis

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Circular RNAs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1087))

Abstract

Fibrosis refers to a process involving the accumulation of extracellular matrix components. It could happen in chronic organ injury or during the recovery of acute organ injury. The severity of fibrosis interferes with the function of the organ involved. Numerous studies have been carried out to explore the mechanism of fibrosis, including parenchyma injury, fibrillar ECM accumulation, fibroblast activation, microvasculature rarefaction, and a mononuclear infiltrate. Unfortunately, its underlying mechanism is at largely unknown. The studying of noncoding RNAs has provided novel insight for circRNA-miRNA-mRNA in learning disease progress. Emerging evidence has shown that circRNA is related to fibrosis activity and could potentially be a monitoring factor for fibrosis or, more excitingly, could be a target for treatment. In this chapter, we will first present the basic mechanism of organ fibrosis. Then we will focus on the recent studies about how circRNA dysregulation contributes to organ fibrosis. Finally, the advantages and potential challenges of circRNA-based therapeutics for the treatment of fibroproliferative diseases will be discussed.

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Acknowledgments

This work was supported by the grants from National Natural Science Foundation of China (81370280 and 81570332 to LZ, 81470515 and 81670362 to JH Xu), Shanghai Medical Guide Project from Shanghai Science and Technology Committee (134119a3000 to Jiahong Xu), and the grant from Jiangsu Province’s Key Provincial Talents Program (ZDRCA2016019 to LZ).

Competing Financial Interests

The authors declare no competing financial interests.

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  1. Author contributed equally with all other contributors.Jianhua Yao and Qiying Dai

Authors and Affiliations

  1. Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

    Jianhua Yao

  2. MetroWest Medical Center, Framingham, MA, USA

    Qiying Dai

  3. Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    Qiying Dai, Zhuyuan Liu & Lei Zhou

  4. Department of Cardiology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, China

    Jiahong Xu

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  1. Jianhua Yao
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  2. Qiying Dai
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  3. Zhuyuan Liu
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  4. Lei Zhou
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  5. Jiahong Xu
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Correspondence to Jiahong Xu .

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Editors and Affiliations

  1. School of Life Science, Institute of Cardiovascular Sciences, Shanghai University, Shanghai, China

    Junjie Xiao

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Yao, J., Dai, Q., Liu, Z., Zhou, L., Xu, J. (2018). Circular RNAs in Organ Fibrosis. In: Xiao, J. (eds) Circular RNAs. Advances in Experimental Medicine and Biology, vol 1087. Springer, Singapore. https://doi.org/10.1007/978-981-13-1426-1_21

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