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Circular RNAs in Cancer

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Circular RNAs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1087))

Abstract

Circular RNAs (circRNAs) constitute a class of RNAs that only recently have come into the focus of the scientific cancer community after it was revealed that they are very abundant, highly conserved across species and show tissue- and developmental stage-specific expression. This tightly regulated, dynamic circRNA expression, in line with expression of messenger RNAs, microRNAs, and long noncoding RNAs, is altered in both solid tumors and hematologic malignancies and most likely contributes to tumorigenesis. In this chapter, we will review cancer-associated and cancer-specific circRNAs, some of which have oncogenic or tumor-suppressive potential. We will specifically focus on circRNAs for which the role in cancer has been studied in more detail, and we will discuss the opportunity to use circRNAs as biomarkers and potential therapeutic targets in cancer.

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Acknowledgments

This work was supported by the Deutsche Forschungsgemeinschaft (SFB 1074 project B3 to LB) and the Studienstiftung des Deutschen Volkes (doctoral grant to SL).

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The authors declare no competing financial interests.

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Authors and Affiliations

  1. Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

    Susanne Lux & Lars Bullinger

  2. Department of Hematology, Oncology and Tumorimmunology, Charité – Universitätsmedizin, Berlin, Germany

    Lars Bullinger

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  1. Susanne Lux
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  2. Lars Bullinger
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Correspondence to Lars Bullinger .

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Editors and Affiliations

  1. School of Life Science, Institute of Cardiovascular Sciences, Shanghai University, Shanghai, China

    Junjie Xiao

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Lux, S., Bullinger, L. (2018). Circular RNAs in Cancer. In: Xiao, J. (eds) Circular RNAs. Advances in Experimental Medicine and Biology, vol 1087. Springer, Singapore. https://doi.org/10.1007/978-981-13-1426-1_17

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