Circular RNAs pp 159-170 | Cite as

Circular RNAs as Novel Biomarkers for Cardiovascular Diseases

  • Qiulian Zhou
  • Zhongrong Zhang
  • Yihua Bei
  • Guoping Li
  • Tianhui WangEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1087)


Cardiovascular diseases are among the most serious diseases, which are a leading cause of death across the world. Early diagnosis and prognosis prediction are keys for treatment and reduction of death rates. Circular RNAs (circRNAs) play a critical role in the physiology and pathology of biological system and participate in the development of diseases. In addition, circRNAs are relative stable and abundant. Therefore, many studies have suggested that circRNAs could be used as biomarkers for diseases, such as neurological diseases, cancers, immune diseases, and digestive diseases. Here we summarize recent studies on circRNAs and compare the characteristics of circRNAs with traditional biomarkers. Finally, we highlight the value of circRNAs as potential biomarkers for cardiovascular diseases, including acute myocardial infarction, heart failure, coronary artery disease, and hypertension. In conclusion, circRNAs may be promising biomarkers for cardiovascular diseases.


Circular RNA Biomarkers Cardiovascular diseases 



This work was supported by the grants from National Natural Science Foundation of China (81770401 to Y Bei) and National Key Research and Development Program of China (2017YFC1700401 to Y Bei).

Competing Financial Interests

The authors declare no competing financial interests.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Qiulian Zhou
    • 1
    • 2
    • 3
  • Zhongrong Zhang
    • 2
    • 3
  • Yihua Bei
    • 2
    • 3
  • Guoping Li
    • 4
  • Tianhui Wang
    • 2
    • 3
    Email author
  1. 1.Shanghai Applied Radiation Institute, School of Environmental and Chemical EngineeringShanghai UniversityShanghaiChina
  2. 2.Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life ScienceShanghai UniversityShanghaiChina
  3. 3.Shanghai Key Laboratory of Bio-Energy CropsSchool of Life SciencesShanghai UniversityChina
  4. 4.Cardiovascular Division of the Massachusetts General HospitalHarvard Medical SchoolBostonUSA

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