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Recombinant Filarial, Wolbachia Antigens and their Role in the Immunopathogenesis of Human Lymphatic Filariasis

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Lymphatic Filariasis

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Abstract

Lymphatic filarial infection prevails in the tropical region and is a serious health problem in India. This is mainly because of the absence of any effective drugs against larval and adult parasites. Therefore, there is a necessity for an alternative strategy to eradicate these parasites. Further, these parasites and their products interfere with effective molecules of innate and adaptive defense responses of the host. This interaction induces modulation in the levels of molecules, and they serve as markers of infection and attributes to the development of the disease. The identification of immune evasion genes from filarial genome project aided in deducing the pathway that leads to chronic disease from infection. This chapter highlights the various mechanisms underlying filarial infection and further characterization of filarial antigens resulted in exploiting them as an effective therapeutic tool against filariasis. Various studies have shown the possible strategies and have identified key molecules for immunological research.

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  1. Department of Biotechnology, Sri Venkateswara College of Engineering (SVCE), Irunkattukottai, Sriperumbudur, India

    Kirthika Sreenivas, Kamalakannan Vijayan & Rangarajan Badri Narayanan

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  1. Kirthika Sreenivas
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  2. Kamalakannan Vijayan
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Correspondence to Rangarajan Badri Narayanan .

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  1. Advisor, SpoRIC, VIT University, Vellore, Tamil Nadu, India

    Brij Kishore Tyagi

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Sreenivas, K., Vijayan, K., Narayanan, R.B. (2018). Recombinant Filarial, Wolbachia Antigens and their Role in the Immunopathogenesis of Human Lymphatic Filariasis. In: Tyagi, B. (eds) Lymphatic Filariasis. Springer, Singapore. https://doi.org/10.1007/978-981-13-1391-2_6

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