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Neural Regulation of Metabolism pp 145–163Cite as

The Leptin Resistance

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1090))

Abstract

Leptin is an adipocyte-derived hormone, which contributes to the homeostatic regulation of energy balance and metabolism through humoral and neural pathways. Leptin acts on the neurons in certain brain areas such as the hypothalamus, hippocampus, and brain stem to regulate food intake, thermogenesis, energy expenditure, and homeostasis of glucose/lipid metabolism. The pathologically increased circulating leptin is a biomarker of leptin resistance, which is common in obese individuals. Leptin resistance is defined by a reduced sensitivity or a failure in response of the brain to leptin, showing a decrease in the ability of leptin to suppress appetite or enhance energy expenditure, which causes an increased food intake and finally leads to overweight, obesity, cardiovascular diseases, and other metabolic disorders. Leptin resistance is a challenge for clinical treatment or drug discovery of obesity. Until recently, emerging evidence has been showing novel mechanisms of the leptin resistance. Here, we summarized the advances and controversy of leptin resistance and associated diseases, for better understanding the physiology and pathophysiology of leptin as well as the new strategies for treating obesity and metabolic disorders.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (No. 81471064, No. 81670779, and No. 81870590), the Beijing Municipal Natural Science Foundation (No. 7162097), the Peking University Research Foundation (No. BMU20140366), and the National Key Research and Development Program of China (2017YFC1700402).

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  1. Authors Jiarui Liu and Xiaoning Yang have equally contributed to this chapter.

Authors and Affiliations

  1. Department of Anatomy, Histology and Embryology, Health Science Center, Peking University, Beijing, China

    Jiarui Liu, Xiaoning Yang & Ruimao Zheng

  2. Neuroscience Research Institute, Peking University, Beijing, China

    Jiarui Liu & Ruimao Zheng

  3. Key Laboratory for Neuroscience of Ministry of Education, Peking University, Beijing, China

    Jiarui Liu & Ruimao Zheng

  4. Key Laboratory for Neuroscience of National Health Commission, Peking University, Beijing, China

    Jiarui Liu & Ruimao Zheng

  5. Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Sciences, Beijing, China

    Siwang Yu

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  1. Jiarui Liu
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  2. Xiaoning Yang
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  3. Siwang Yu
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  4. Ruimao Zheng
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Corresponding author

Correspondence to Ruimao Zheng .

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Editors and Affiliations

  1. Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA

    Qi Wu

  2. Department of Anatomy, Histology and Embryology, Health Science Center, Peking University, Beijing, China

    Ruimao Zheng

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Liu, J., Yang, X., Yu, S., Zheng, R. (2018). The Leptin Resistance. In: Wu, Q., Zheng, R. (eds) Neural Regulation of Metabolism. Advances in Experimental Medicine and Biology, vol 1090. Springer, Singapore. https://doi.org/10.1007/978-981-13-1286-1_8

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