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Neural Regulation of Metabolism pp 123–144Cite as

The Leptin Signaling

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1090))

Abstract

Leptin plays a critical role in the regulation of energy balance and metabolic homeostasis. Impairment of leptin signaling is closely involved in the pathogenesis of obesity and metabolic diseases, including diabetes, cardiovascular disease, etc. Leptin initiates its intracellular signaling in the leptin-receptor-expressing neurons in the central nervous system to exert physiological function, thereby leading to a suppression of appetite, a reduction of food intake, a promotion of mitochondrial oxidation, an enhancement of thermogenesis, and a decrease in body weight. In this review, the studies on leptin neural and cellular pathways are summarized with an emphasis on the progress made during the last 10 years, for better understanding the molecular mechanism of obesity and other metabolic diseases.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (No. 81471064, No. 81670779 and No. 81870590), the Beijing Municipal Natural Science Foundation (No. 7162097), the Peking University Research Foundation (No. BMU20140366), and the National Key Research and Development Program of China (2017YFC1700402).

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  1. Authors Jiarui Liu and Xiaoning Yang have equally contributed to this chapter.

Authors and Affiliations

  1. Department of Anatomy, Histology and Embryology, Health Science Center, Peking University, Beijing, China

    Jiarui Liu, Xiaoning Yang & Ruimao Zheng

  2. Neuroscience Research Institute, Peking University, Beijing, China

    Jiarui Liu & Ruimao Zheng

  3. Key Laboratory for Neuroscience of Ministry of Education, Peking University, Beijing, China

    Jiarui Liu & Ruimao Zheng

  4. Key Laboratory for Neuroscience of National Health Commission, Peking University, Beijing, China

    Jiarui Liu & Ruimao Zheng

  5. Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Sciences, Beijing, China

    Siwang Yu

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  1. Jiarui Liu
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  2. Xiaoning Yang
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  3. Siwang Yu
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  4. Ruimao Zheng
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Correspondence to Ruimao Zheng .

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Editors and Affiliations

  1. Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA

    Qi Wu

  2. Department of Anatomy, Histology and Embryology, Health Science Center, Peking University, Beijing, China

    Ruimao Zheng

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Liu, J., Yang, X., Yu, S., Zheng, R. (2018). The Leptin Signaling. In: Wu, Q., Zheng, R. (eds) Neural Regulation of Metabolism. Advances in Experimental Medicine and Biology, vol 1090. Springer, Singapore. https://doi.org/10.1007/978-981-13-1286-1_7

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