Gastric Cancer Worldwide Except Japan
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Until recently, gastric cancer was the most common cause of cancer deaths. Despite the rapid fall in incidence, gastric cancer is still the fifth most common cancer and third leading cause of cancer-related mortality worldwide. The lifetime risk of gastric cancer to age 74 remains between 1 and 3% in most European countries and as high as 5–20% in some parts of Asia. The discovery of Helicobacter pylori as the cause of atrophic gastritis, the lesion that predisposes to gastric cancer, has resulted in increasing attempts to eliminate gastric cancer by eradicating H. pylori. Here we review the worldwide changes in gastric cancer incidence and the current lifetime risk.
KeywordsGastric cancer Epidemiology Helicobacter pylori Epidemiology Risk factors
Support: Dr. Graham is supported in part by the Office of Research and Development Medical Research Service Department of Veterans Affairs, Public Health Service grant DK56338 which funds the Texas Medical Center Digestive Diseases Center.
Disclosures: Dr. Graham is a consultant for RedHill Biopharma regarding novel H. pylori therapies and has received research support for culture of Helicobacter pylori and is the PI of an international study of the use of antimycobacterial therapy for Crohn’s disease. He is also a consultant for BioGaia in relation to probiotic therapy for H. pylori infection and for Takeda in relation to H. pylori therapies. Drs. Tan and Balakrishnan do not have any relevant disclosures.
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