Prevention Strategy for Gastric Cancer
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In Japan, the major cause of gastric cancer is Helicobacter pylori infection. Therefore, targeting H. pylori eradication is considered an effective strategy to prevent gastric carcinogenesis. However, the prevention strategy should be decided based on the risk of individual patients. The risk of gastric cancer has been reported to depend on the severity of atrophic mucosa caused by Helicobacter pylori, and the earlier H. pylori eradication has been thought to be more effective in the prevention of future gastric carcinogenesis. Consequently, there are several “screen-and-treat” projects at the prefectural level in Japan for junior high and high school students. On the contrary to the high-risk group, the severity of gastric mucosal atrophy is much severer than the younger generation, and follow-up surveillance for gastric cancer is more important in addition to H. pylori eradication.
KeywordsHelicobacter pylori Younger generation Student Screen and treat Gastric cancer
- 4.Ono S, Kato M, Suzuki M, Ishigaki S, Takahashi M, Haneda M, Mabe K, Shimizu Y. Frequency of Helicobacter pylori-negative gastric cancer and gastric mucosal atrophy in a Japanese endoscopic submucosal dissection series including histological, endoscopic and serological atrophy. Digestion. 2012;86(1):59–65.CrossRefGoogle Scholar
- 26.Sasaki M, Ogasawara N, Utsumi K, Kawamura N, Kamiya T, Kataoka H, Tanida S, Mizoshita T, Kasugai K, Joh T. Changes in 12-year first-line eradication rate of Helicobacter pylori based on triple therapy with proton pump inhibitor, amoxicillin and clarithromycin. J Clin Biochem Nutr. 2010;47(1):53–8.CrossRefGoogle Scholar
- 27.Murakami K, Sakurai Y, Shiino M, Funao N, Nishimura A, Asaka M. Vonoprazan, a novel potassium-competitive acid blocker, as a component of first-line and second-line triple therapy for Helicobacter pylori eradication: a phase III, randomised, double-blind study. Gut. 2016;65(9):1439–46.CrossRefGoogle Scholar