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Epigenetic Regulation of Vascular Aging and Age-Related Vascular Diseases

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Aging and Aging-Related Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1086))

Abstract

Vascular aging refers to the structural and functional defects that occur in the aorta during the aging process and is characterized by increased vascular cell senescence, vascular dyshomeostasis, and vascular remodeling. Vascular aging is a major risk factor for vascular diseases. However, the current understanding of the biological process of vascular aging and age-related diseases is insufficient. Epigenetic regulation can influence gene expression independently of the gene sequence and mainly includes DNA methylation, histone modifications, and RNA-based gene regulation. Epigenetic regulation plays important roles in many physiological and pathophysiological processes and may explain some gaps in our knowledge regarding the interaction between genes and diseases. In this review, we summarize recent advances in the understanding of the epigenetic regulation of vascular aging and age-related diseases in terms of vascular cell senescence, vascular dyshomeostasis, and vascular remodeling. Moreover, the possibility of targeting epigenetic regulation to delay vascular aging and treat age-related vascular diseases is also discussed.

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Acknowledgments

We thank Siyao Qu for drawing the illustrations for this review. This work was supported by grants from the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (CIFMS2017-I2M-1-008), the Medical Epigenetics Research Center, Chinese Academy of Medical Sciences (2017PT31035), and the National Natural Science Foundation of China (nos. 81701387, 91639304, and 31571193). Dr. H.Z. Chen is also supported by the Youth Top-notch Talent Support Program and the Youth Yangtze River Scholar Program in China.

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  1. State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

    Yang-Nan Ding, Xiaoqiang Tang, Hou-Zao Chen & De-Pei Liu

  2. Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China

    Xiaoqiang Tang

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  1. Yang-Nan Ding
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Correspondence to Hou-Zao Chen or De-Pei Liu .

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  1. School of Pharmaceutical Sciences, Tsinghua University, Beijing, China

    Zhao Wang

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Ding, YN., Tang, X., Chen, HZ., Liu, DP. (2018). Epigenetic Regulation of Vascular Aging and Age-Related Vascular Diseases. In: Wang, Z. (eds) Aging and Aging-Related Diseases. Advances in Experimental Medicine and Biology, vol 1086. Springer, Singapore. https://doi.org/10.1007/978-981-13-1117-8_4

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