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Aging and Aging-Related Diseases pp 169–187Cite as

Aging Kidney and Aging-Related Disease

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1086))

Abstract

With the development of society and improvement of health care, the life span is much longer than before, which brings serious aging problems. Among all the aging problems, renal aging grows to be nonnegligible issue. The aging process of kidney is always accompanied with structural and functional changes. Molecular changes, including Klotho and Sirtuins, are the basic causes of phenotypical changes. Cell senescence and cell autophagy play fundamental roles in the process of renal aging. To effectively intervene in the process of renal aging, different methods have been tried separately, which could produce different effects. Effective intervention of renal aging could be meaningful for healthy state of the whole body.

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Acknowledgements

This work was financially supported by grants from the National Key R&D Program of China (2018YFD0400204), the Key International S&T Cooperation Program of China (2016YFE113700), the European Union’s Horizon 2020 Research and Innovation Program (633589) and the National Natural Science Foundation of China (81471396).

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  1. MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China

    Zhongchi Li

  2. School of Pharmaceutical Sciences, Tsinghua University, Beijing, China

    Zhao Wang

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    Zhao Wang

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Li, Z., Wang, Z. (2018). Aging Kidney and Aging-Related Disease. In: Wang, Z. (eds) Aging and Aging-Related Diseases. Advances in Experimental Medicine and Biology, vol 1086. Springer, Singapore. https://doi.org/10.1007/978-981-13-1117-8_11

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