Skip to main content
SpringerLink
Log in

Genetic Factor

  • Chapter
  • First Online:
Functional Dyspepsia

  • 421 Accesses

Abstract

Symptoms can be considered as uncomfortable feelings against some stimulation. How humans react for the stimulation is basically prescribed by genetic factors, which is altered by the acquired factors. We found that the genetic polymorphisms in three genes, TRPV1, pri-miR325 genome region, and SCN10A, were associated with the susceptibility to functional dyspepsia (FD). These polymorphisms were also associated with both FD subtypes, epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS), as a same degree. In Helicobacter pylori (HP)-uninfected subjects, the polymorphisms in pri-miR325 genome region, SCN10A, and GNB3 were associated with FD, whereas the polymorphisms in TRPV1 and inflammation- and immune response-related genes were associated with FD in HP-infected subjects. From a viewpoint of genetic polymorphisms associated with FD susceptibility, EPS and PDS defined by Roma III criteria may be the same disorder with the difference in complaints. In addition, the hypersensitivity of stimulation-conducting system may be important in HP-unrelated dyspepsia (namely true FD), whereas inflammation severity and alteration of nociceptor may be important in HP-related dyspepsia.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Locke GR 3rd, Zinsmeister AR, Talley NJ, Fett SL, Melton LJ 3rd. Familial association in adults with functional gastrointestinal disorders. Mayo Clin Proc. 2000;75:907–12.

    Article  PubMed  Google Scholar 

  2. Gathaiya N, Locke GR 3rd, Camilleri M, Schleck CD, Zinsmeister AR, Talley NJ. Novel associations with dyspepsia: a community-based study of familial aggregation, sleep dysfunction and somatization. Neurogastroenterol Motil. 2009;21:922–e69.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Holtmann G, Siffert W, Haag S, Mueller N, Langkafel M, Senf W, et al. G-protein beta 3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsia. Gastroenterology. 2004;126:971–9.

    Article  CAS  PubMed  Google Scholar 

  4. Baumgart D, Naber C, Haude M, Oldenburg O, Erbel R, Heusch G, et al. G protein beta3 subunit 825T allele and enhanced coronary vasoconstriction on alpha(2)-adrenoceptor activation. Circ Res. 1999;85:965–9.

    Article  CAS  PubMed  Google Scholar 

  5. Camilleri CE, Carlson PJ, Camilleri M, Castillo EJ, Locke GR 3rd, Geno DM, et al. A study of candidate genotypes associated with dyspepsia in a U.S. community. Am J Gastroenterol. 2006;101:581–92.

    Article  CAS  PubMed  Google Scholar 

  6. van Lelyveld N, Linde JT, Schipper M, Samsom M. Candidate genotypes associated with functional dyspepsia. Neurogastroenterol Motil. 2008;20:767–73.

    Article  CAS  PubMed  Google Scholar 

  7. Thara T, Arisawa T, Shibata T, Wang F, Nakamura M, Sakata M, et al. Homozygous 825T allele of the GNB3 protein influences the susceptibility of Japanese to dyspepsia. Dig Dis Sci. 2008;53:642–6.

    Article  CAS  Google Scholar 

  8. Oshima T, Nakajima S, Yokoyama T, Toyoshima F, Sakurai J, Tanaka J, et al. The G-protein β3 subunit 825 TT genotype is associated with epigastric pain syndrome-like dyspepsia. BMC Med Genet. 2010;11:13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Shimpuku M, Futagami S, Kawagoe T, Nagoya H, Shindo T, Horie A, et al. G-protein β3 subunit 825CC genotype is associated with postprandial distress syndrome with impaired gastric emptying and with the feeling of hunger in Japanese. Neurogastroenterol Motil. 2011;23:1073–e535.

    Article  CAS  PubMed  Google Scholar 

  10. Kim HG, Lee KJ, Lim SG, Jung JY, Cho SW. G-protein beta3 subunit C825T polymorphism in patients with overlap syndrome of functional dyspepsia and irritable bowel syndrome. J Neurogastroentrol Motil. 2012;18:205–10.

    Article  Google Scholar 

  11. Tahara T, Shibata T, Nakamura M, Yamashita H, Yoshioka D, Hirata I, et al. Homozygous TRPV1 315C influences the susceptibility to functional dyspepsia. J Clin Gastroenterol. 2010;44:e1–7.

    Article  CAS  PubMed  Google Scholar 

  12. Arisawa T, Tahara T, Shiroeda H, Minato T, Matsue Y, Saito T, et al. Genetic polymorphisms of SCN10A are associated with functional dyspepsia in Japanese subjects. J Gastroenterol. 2013;48:73–80.

    Article  CAS  PubMed  Google Scholar 

  13. Arisawa T, Tahara T, Fukuyama T, Hayashi R, Matsunaga K, Hayashi N, et al. Genetic polymorphism of pri-microRNA 325, targeting SLC6A4 3’-UTR, is closely associated with the risk of functional dyspepsia in Japan. J Gastroenterol. 2012;47:1091–8.

    Article  CAS  PubMed  Google Scholar 

  14. Taniguchi M, Mashita Y, Matsuzaka S, Kato S, Takeuchi K. Role of capsaicin-sensitive afferent neurons in receptive relaxation induced by gastric distension in rats. Inf Dent. 2007;15:273–7.

    CAS  Google Scholar 

  15. Bortolotti M, Coccia G, Grossi G, Miglioli M. The treatment of functional dyspepsia with red pepper. Aliment Pharmacol Ther. 2002;16:1075–82.

    Article  CAS  PubMed  Google Scholar 

  16. Tominaga K, Tsumoto C, Ataka S, Mizuno K, Takahashi K, Yamagami H, et al. Regional brain disorders of serotonin neurotransmission are associated with functional dyspepsia. Life Sci. 2015;137:150–7.

    Article  CAS  PubMed  Google Scholar 

  17. Akopian AN, Souslova V, England S, Okuse K, Ogata N, Ure J, et al. The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat Neurosci. 1999;2:541–8.

    Article  CAS  PubMed  Google Scholar 

  18. Chambers JC, Zhao J, Terracciano CM, Bezzina CR, Zhang W, Kaba R, et al. Genetic variation in SCN10A influences cardiac conduction. Nat Genet. 2010;42:149–52.

    Article  CAS  PubMed  Google Scholar 

  19. Arisawa T, Tahara T, Shibata T, Nagasaka M, Nakamura M, Kamiya Y, et al. Genetic polymorphisms of molecules associated with inflammation and immune response in Japanese subjects with functional dyspepsia. Int J Mol Med. 2007;20:717–23.

    PubMed  CAS  Google Scholar 

  20. Tahara T, Shibata T, Yamashita H, Hirata I, Arisawa T. The role of RANTES promoter polymorphism in functional dyspepsia. J Clin Biochem Nutr. 2009;45:235–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Tahara T, Shibata T, Wang F, Nakamura M, Sakata M, Nakano H, et al. A genetic variant of the p22PHOX component of NADPH oxidase C242T is associated with reduced risk of functional dyspepsia in helicobacter pylori-infected Japanese individuals. Eur J Gastroenterol Hepatol. 2009;21:1363–8.

    Article  PubMed  Google Scholar 

  22. Tahara T, Shibata T, Wang F, Yamashita H, Hirata I, Arisawa T. Genetic polymorphisms of molecules associated with innate immune responses, TRL2 and MBL2 genes in Japanese subjects with functional dyspepsia. J Clin Biochem Nutr. 2010;47:217–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Tahara T, Arisawa T, Shibata T, Nakamura M, Okubo M, Yoshioka D, et al. Association of endoscopic appearances with dyspeptic symptoms. J Gastroenterol. 2008;43:208–15.

    Article  PubMed  Google Scholar 

  24. Moayyedi P, Soo S, Deeks JJ, Delaney B, Harris A, Innes M, et al. Eradication of helicobacter pylori for non-ulcer dyspepsia. Cochrane Database Syst Rev. 2009;19:C002096.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gastroenterology, Kanazawa Medical University, Uchinada-machi, Ishikawa, Japan

    Tomiyasu Arisawa

Authors
  1. Tomiyasu Arisawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tomiyasu Arisawa .

Editor information

Editors and Affiliations

  1. Premier Developmental Research of Medicine, Osaka Medical College, Takatsuki, Osaka, Japan

    Kazunari Tominaga

  2. Department of General Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan

    Hiroaki Kusunoki

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Arisawa, T. (2018). Genetic Factor. In: Tominaga, K., Kusunoki, H. (eds) Functional Dyspepsia. Springer, Singapore. https://doi.org/10.1007/978-981-13-1074-4_2

Download citation

  • DOI: https://doi.org/10.1007/978-981-13-1074-4_2

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-1073-7

  • Online ISBN: 978-981-13-1074-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation