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Cutting-Edge Enabling Technologies for Regenerative Medicine pp 233–244Cite as

Bone Tissue Engineering Strategies in Co-Delivery of Bone Morphogenetic Protein-2 and Biochemical Signaling Factors

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1078))

Abstract

Administration of bone morphogenetic protein-2 (BMP-2), which is commercially approved by the food and drug administration to damaged bone sites has been investigated for the purpose of bone tissue regeneration. BMP-2 can promote osteoblastic differentiation of mesenchymal stem cells as well as regeneration of bone formation in early phase. This review highlights various factors such as vitamin D, dexamethasone, platelet-derived growth factor, placental growth factor, BMP-7, and NEL-like protein-1 that enhance and stimulate angiogenesis, cell differentiation, and bone regeneration. These biochemical signals and growth factors (GFs) accelerate bone repair and remodeling either synergistically or individually. Delivery systems and scaffolds are used for sustained release of these cargo molecules and support at damaged bone sites. Compared with direct administration of BMP-2, current studies have demonstrated that a combination of multiple GFs and/or therapeutic chemical factors with delivery platforms synergistically facilitates bone regeneration. Therefore, in the future, multiple combinations of various GFs, chemicals, and materials could provide patients and surgeons with non-invasive treatment options without secondary surgery and pain. To the end, this review summarizes the biological functions and synergistic effects of dual administration modalities involving BMP-2 as well as recent developments in bone tissue engineering applications.

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Acknowledgment

This research was supported by Incheon National University Research Grant (2015).

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  1. Sungjun Kim and Sangmin Lee have contributed equally in this chapter.

Authors and Affiliations

  1. Division of Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, Incheon, South Korea

    Sungjun Kim & Kyobum Kim

  2. Department of Bioengineering, Hanyang University, Seoul, South Korea

    Sangmin Lee

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  1. Sungjun Kim
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  2. Sangmin Lee
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Correspondence to Kyobum Kim .

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Editors and Affiliations

  1. The Catholic University of Korea, Seoul, Korea (Republic of)

    Heung Jae Chun

  2. Hallym University, Gangwon-do, Korea (Republic of)

    Chan Hum Park

  3. Kyung Hee University, Seoul, Korea (Republic of)

    Il Keun Kwon

  4. Chonbuk National University, Jeonju, Korea (Republic of)

    Gilson Khang

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Kim, S., Lee, S., Kim, K. (2018). Bone Tissue Engineering Strategies in Co-Delivery of Bone Morphogenetic Protein-2 and Biochemical Signaling Factors. In: Chun, H., Park, C., Kwon, I., Khang, G. (eds) Cutting-Edge Enabling Technologies for Regenerative Medicine. Advances in Experimental Medicine and Biology, vol 1078. Springer, Singapore. https://doi.org/10.1007/978-981-13-0950-2_12

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