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Naturally-Derived Biomaterials for Tissue Engineering Applications

  • Matthew Brovold
  • Joana I. Almeida
  • Iris Pla-Palacín
  • Pilar Sainz-Arnal
  • Natalia Sánchez-Romero
  • Jesus J. Rivas
  • Helen Almeida
  • Pablo Royo Dachary
  • Trinidad Serrano-Aulló
  • Shay SokerEmail author
  • Pedro M. BaptistaEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1077)

Abstract

Naturally-derived biomaterials have been used for decades in multiple regenerative medicine applications. From the simplest cell microcarriers made of collagen or alginate, to highly complex decellularized whole-organ scaffolds, these biomaterials represent a class of substances that is usually first in choice at the time of electing a functional and useful biomaterial. Hence, in this chapter we describe the several naturally-derived biomaterials used in tissue engineering applications and their classification, based on composition. We will also describe some of the present uses of the generated tissues like drug discovery, developmental biology, bioprinting and transplantation.

Keywords

Naturally-derived materials Tissue decellularization Tissue engineering Protein-based biomaterials Polysaccharide-based biomaterials Glycosaminoglycans Extracellular matrix-derived biomaterials Solid organ bioengineering Regulatory landscape for naturally-derived biomaterials 

Notes

Acknowledgements

This work was supported by Gobierno de Aragón and Fondo Social Europeo through a predoctoral Fellowship DGA C066/2014 (P. S-A), Instituto de Salud Carlos III, through a predoctoral fellowship i-PFIS IFI15/00158 (I. P-P). N. S-R was supported by a POCTEFA/Refbio II research grant and FGJ Gobierno de Aragón. J.I.A was supported by Fundação para a Ciência e a Tecnologia (Portugal), through a predoctoral Fellowship SFRH/BD/116780/2016. PMB was supported with the project PI15/00563 from Instituto de Salud Carlos III, Spain.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Matthew Brovold
    • 1
  • Joana I. Almeida
    • 2
  • Iris Pla-Palacín
    • 2
  • Pilar Sainz-Arnal
    • 2
    • 3
  • Natalia Sánchez-Romero
    • 2
  • Jesus J. Rivas
    • 2
  • Helen Almeida
    • 2
  • Pablo Royo Dachary
    • 4
    • 5
  • Trinidad Serrano-Aulló
    • 4
    • 5
  • Shay Soker
    • 1
    Email author
  • Pedro M. Baptista
    • 4
    • 6
    • 7
    • 8
    • 9
    Email author
  1. 1.Wake Forest Institute for Regenerative MedicineWinston-SalemUSA
  2. 2.Health Research Institute of Aragón (IIS Aragón)ZaragozaSpain
  3. 3.Aragon Health Sciences Institute (IACS)ZaragozaSpain
  4. 4.Instituto de Investigación Sanitária de Aragón (IIS Aragón)ZaragozaSpain
  5. 5.Liver Transplant Unit, Gastroenterology DepartmentLozano Blesa University HospitalZaragozaSpain
  6. 6.Center for Biomedical Research Network Liver and Digestive Diseases (CIBERehd)ZaragozaSpain
  7. 7.Instituto de Investigación Sanitaria de la Fundación Jiménez DíazMadridSpain
  8. 8.Biomedical and Aerospace Engineering DepartmentUniversidad Carlos III de MadridMadridSpain
  9. 9.Fundación ARAIDZaragozaSpain

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