Medical Applications of Collagen and Hyaluronan in Regenerative Medicine

  • Lynn L. H. HuangEmail author
  • Ying-Hui Amy Chen
  • Zheng-Ying Zhuo
  • Ya-Ting Hsieh
  • Chia-Ling Yang
  • Wei-Ting Chen
  • Jhih-Ying Lin
  • You-Xin Lin
  • Jian-Ting Jiang
  • Chao-Hsung Zhuang
  • Yi-Ching Wang
  • Hanhhieu Nguyendac
  • Kai-Wei Lin
  • Wen-Lung Liu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1077)


In order to develop and commercialize for the regenerative medicinal products, smart biomaterials with biocompatibility must be needed. In this chapter, we introduce collagen and hyaluronic acid (HA) as extracellular matrix as well as deal with the molecular mechanism as microenvironment, mechanistic effects, and gene expression. Application of collagen and HA have been reviewed in the area of orthopedics, orthopedics, ophthalmology, dermatology and plastic surgery. Finally, the ongoing and commercial products of collagen and HA for regenerative medicine have been introduced.


Collagen Hyaluronic acid Biomaterial 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Lynn L. H. Huang
    • 1
    • 2
    • 3
    • 4
    Email author
  • Ying-Hui Amy Chen
    • 1
  • Zheng-Ying Zhuo
    • 1
  • Ya-Ting Hsieh
    • 3
  • Chia-Ling Yang
    • 3
  • Wei-Ting Chen
    • 3
  • Jhih-Ying Lin
    • 1
  • You-Xin Lin
    • 1
  • Jian-Ting Jiang
    • 1
  • Chao-Hsung Zhuang
    • 1
  • Yi-Ching Wang
    • 1
  • Hanhhieu Nguyendac
    • 1
  • Kai-Wei Lin
    • 3
  • Wen-Lung Liu
    • 3
  1. 1.Department of Biotechnology and Bioindustry Sciences, College of Bioscience and BiotechnologyNational Cheng Kung UniversityTainanTaiwan
  2. 2.Institute of Clinical Medicine, College of MedicineNational Cheng Kung UniversityTainanTaiwan
  3. 3.Research Center of Excellence in Regenerative MedicineNational Cheng Kung UniversityTainanTaiwan
  4. 4.International Research Center for Wound Repair and RegenerationTainanTaiwan

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