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Non-coding RNAs in Complex Diseases pp 65–75Cite as

Aberrant Epigenetic Modifications of Non-coding RNAs in Human Disease

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1094))

Abstract

Non-coding RNAs, especially lncRNAs, have emerged as key components in histone modification. The alterations in the epigenetic modifications of lncRNAs underlie some human disorders ranging from neurodegeneration to cancer. To characterize the epigenetic modifications of lncRNAs, we first constructed the histone modification maps of various epigenetic markers across different cell lines. Then, we developed a method to identify epigenetically regulated lncRNAs and their response genes by integrating large scale epigenetic and transcriptional profiles. Our results showed that epigenetic alterations at the promoters of lncRNAs can influence their expression and the negative response genes of most epigenetically regulated lncRNAs were enriched for PRC2-binding genes. At last, we inferred some lncRNAs with aberrant epigenetic modifications in glioblastoma and Alzheimer’s disease, and proved that theses lncRNAs may contribute to the initiation of human diseases.

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Author information

Authors and Affiliations

  1. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China

    Yun Xiao, Jinyuan Xu & Wenkang Yin

Authors
  1. Yun Xiao
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  2. Jinyuan Xu
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  3. Wenkang Yin
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Corresponding author

Correspondence to Yun Xiao .

Editor information

Editors and Affiliations

  1. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China

    Xia Li

  2. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China

    Juan Xu

  3. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China

    Yun Xiao

  4. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China

    Shangwei Ning

  5. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China

    Yunpeng Zhang

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© 2018 Springer Nature Singapore Pte Ltd.

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Xiao, Y., Xu, J., Yin, W. (2018). Aberrant Epigenetic Modifications of Non-coding RNAs in Human Disease. In: Li, X., Xu, J., Xiao, Y., Ning, S., Zhang, Y. (eds) Non-coding RNAs in Complex Diseases. Advances in Experimental Medicine and Biology, vol 1094. Springer, Singapore. https://doi.org/10.1007/978-981-13-0719-5_7

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