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Association of Circulating Oxidized Lipids with Cardiovascular Outcomes

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Lipidomics in Health & Disease

Part of the book series: Translational Bioinformatics ((TRBIO,volume 14))

Abstract

Multiple studies established the causal relationship between elevated levels of low density lipoproteins (LDL) and their oxidized modifications, oxidized LDL, and atherosclerosis. However, while it is generally recognized that LDL oxidation occurs mainly in the sub-endothelial space within the vascular wall, the role of circulating oxLDL in the development of the disease remains a matter of debate. There is also significant confusion in the field regarding the levels of oxLDL that occur in vivo, partly because of the complex and heterogeneous nature of the oxLDL particle and the discrepancies between the methods used for its detection. In this chapter, therefore, we first present different analytical methods used to evaluate the level, the state of oxidation and the lipid composition of oxLDL, which represents the basis of the lipidomics analysis of the circulating LDL. This is followed by presenting the current state of knowledge about the levels of circulating oxLDL and its two major components, oxidized phospholipids, oxPCs and oxysterols in human plasma and their association with the cardiovascular outcomes across multiple studies and cohorts of patients. Taken together, these studies present strong evidence for the circulating oxLDL and specific oxysterols to constitute independent risk factors for the development of atherosclerosis.

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Acknowledgements

We are grateful to Mr. Gregory Kowalsky for helping with the preparation of the figures. This study is supported by NIH grants HL-073965 and HL-083298 to I.L.

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Authors and Affiliations

  1. Division of Pulmonary and Critical Care, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA

    Irena Levitan & Ibra S. Fancher

  2. National Jewish Health, Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Denver, CO, USA

    Evgeny Berdyshev

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  1. Irena Levitan
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  2. Ibra S. Fancher
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Correspondence to Irena Levitan .

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Editors and Affiliations

  1. Zhongshan Hospital Institute of Clinical Science, Fudan University Shanghai Medical College, Shanghai, China

    Xiangdong Wang

  2. Zhongshan Hospital Institute of Clinical Science, Fudan University Shanghai Medical School, Shanghai, China

    Duojiao Wu

  3. Institutes of Biomedicine, Fudan University, Shanghai, China

    Huali Shen

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Levitan, I., Fancher, I.S., Berdyshev, E. (2018). Association of Circulating Oxidized Lipids with Cardiovascular Outcomes. In: Wang, X., Wu, D., Shen, H. (eds) Lipidomics in Health & Disease. Translational Bioinformatics, vol 14. Springer, Singapore. https://doi.org/10.1007/978-981-13-0620-4_9

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