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Lipidomics in Carotid Artery Stenosis: Further Understanding of Pathology and Treatment

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Lipidomics in Health & Disease

Part of the book series: Translational Bioinformatics ((TRBIO,volume 14))

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Abstract

Lipidomics, a novel emerging “-omics” technology, focusing on identification and quantification of large-scale lipid molecules in organelle, cell, tissue and organism, provides a comprehensive lipid profile of sample instead of confined molecules and provokes insights into biomedical and healthy study. “-omics” technologies are getting widely used recently in the identification of biomarkers for diagnosis, prediction, and therapy of diseases, among which lipidomics mainly in lipid-related diseases. Besides, lipidomics also plays a role in translational medicine and other medical researches. Many vascular diseases like stenosis are lipid-related, so the application of this novel technology attracts our attention. Among those diseases, we will concentrate on the utility of lipidomics in carotid artery stenosis, of which usual pathology is atherosclerosis being wildly thought due to dyslipidemia. Furthermore, we will also evaluate the techniques used in lipidomics, the data analysis and its combination with other “-omics” technologies. Reflection on its present limitations and prospective in carotid stenosis study is also reviewed and conclusions which might promote further development of the lipidomics are drawn.

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Authors and Affiliations

  1. Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Vascular Surgery Institute of Fudan University, Shanghai, China

    Wei Zhang, Xiushi Zhou, Daqiao Guo, Weiguo Fu & Lixin Wang

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  1. Wei Zhang
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  2. Xiushi Zhou
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  3. Daqiao Guo
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  4. Weiguo Fu
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  5. Lixin Wang
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Correspondence to Lixin Wang .

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Editors and Affiliations

  1. Zhongshan Hospital Institute of Clinical Science, Fudan University Shanghai Medical College, Shanghai, China

    Xiangdong Wang

  2. Zhongshan Hospital Institute of Clinical Science, Fudan University Shanghai Medical School, Shanghai, China

    Duojiao Wu

  3. Institutes of Biomedicine, Fudan University, Shanghai, China

    Huali Shen

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Zhang, W., Zhou, X., Guo, D., Fu, W., Wang, L. (2018). Lipidomics in Carotid Artery Stenosis: Further Understanding of Pathology and Treatment. In: Wang, X., Wu, D., Shen, H. (eds) Lipidomics in Health & Disease. Translational Bioinformatics, vol 14. Springer, Singapore. https://doi.org/10.1007/978-981-13-0620-4_5

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