Abstract
Multivariate data methods have been applied in analysis of parameters derived from patients with metabolic syndrome undergoing a remedial regime. In an example involving parameters derived from the fatty acid composition of serum lipids multivariate modeling is challenged to identify potential biomarkers for prediction during the intervention. Multivariate methods also reveal useful applications to monitor compliance to the prescribed exercise and diet regime, a critical feature in a lifestyle intervention conducted over a long time period.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ajala O, English P, Pinkney J. Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes. Am J Clin Nutr. 2013;97(3):505–16. https://doi.org/10.3945/ajcn.112.042457.Am.
Alberti KG, Zimmet P, Shaw J. The metabolic syndrome [mdash] a new worldwide definition. Lancet. 2005;366:1059–62. Retrieved from https://doi.org/10.1016/S0140-6736(05)67402-8
Alberti KGMM, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC. Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; National heart, lung, and blood institute; American heart association; World heart federation; International. Circulation. 2009;120(16):1640–5. https://doi.org/10.1161/CIRCULATIONAHA.109.192644.
Bigornia SJ, Lichtenstein AH, Harris WS, Tucker KL. Associations of erythrocyte fatty acid patterns with insulin resistance. Am J Clin Nutr. 2016;103(3):902–9. https://doi.org/10.3945/ajcn.115.123604.
Borges, Jorge Louis. Funes ou la Memoire. Journal La Nación. 1942
Castro-Gómez P, Fontecha J, Rodríguez-Alcalá LM. A high-performance direct transmethylation method for total fatty acids assessment in biological and foodstuff samples. Talanta. 2014;128:518–23. https://doi.org/10.1016/j.talanta.2014.05.051.
Danaei G. Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1.8 million participants. Lancet. 2014;383(9921):970–83. https://doi.org/10.1016/S0140-6736(13)61836-X.
Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Investig. 2005;115(5):1343–51. https://doi.org/10.1172/jci23621.
Dutheil F, Lac G, Courteix D, Doré E, Chapier R, Roszyk L, Sapin V, Lesourd B. Treatment of metabolic syndrome by combination of physical activity and diet needs an optimal protein intake: a randomized controlled trial. Nutr J. 2012;11(1):72. https://doi.org/10.1186/1475-2891-11-72.
Dutheil F, Lac G, Lesourd B, Chapier R, Walther G, Vinet A, Sapin V, Verney J, Ouchchane L, Duclos M, Obert P, Courteix D. Different modalities of exercise to reduce visceral fat mass and cardiovascular risk in metabolic syndrome: the RESOLVE* randomized trial. Int J Cardiol. 2013;168(4):3634–42. https://doi.org/10.1016/j.ijcard.2013.05.012.
Dutheil F, Walther G, Chapier R, Mnatzaganian G, Lesourd B, Naughton G, Verney J, Fogli A, Sapin V, Duclos M, Vinet A, Obert P, Courteix D, Lac G. Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet – the RESOLVE trial. Lipids Health Dis. 2014;13:112. https://doi.org/10.1186/1476-511X-13-112.
Eriksson I, Johannson E, Kettansh-Wold N, Wold S. Multi- and megavariate analysis. Principles and applications. Umeå: Umetrics Academy; 2001. 533 p. ISBN 91-973730-1-X.
Eriksson, et al. Multi- and megavariate data analysis. Technometrics. 2013;45(4):362–362. https://doi.org/10.1198/tech.2003.s162
Hashimoto S, Yatsuhashi H, Abiru S, Yamasaki K, Komori A, Nagaoka S, Saeki A, Uchida S, Bekki S, Kugiyama Y, Nagata K, Nakamura M, Migita K, Nakao K. Rapid increase in serum low-density lipoprotein cholesterol concentration during hepatitis C interferon-free treatment. PLoS One. 2016;28:11(9).
Holman RT. The ratio of trienoic: tetraenoic acids in tissue lipids as a measure of essential fatty acid requirement. J Nutr. 1960;70:405–10.
Huang CW, Chien YS, Chen YJ, Ajuwon KM, Mersmann HM, Ding ST. Role of n-3 polyunsaturated fatty acids in amelorating the obesity-induced metabolic syndrome in animal models and humans. Int J Mol Sci. 2016;17(10) pii: E1689. DOI: https://doi.org/10.3390/ijms17101689
Inoue T, Goto T, Iio E, Matsunami K, Fujiwara K, Shinkai N, Matsuura K, Matsui T, Nojiri S Tanaka Y. Changes in serum lipid profiles caused by three regimens of interferon-free direct-acting antivirals for patients infected with hepatitis C virus. Hepatol Res. 2017; Aug 19. https://doi.org/10.1111/hepr.12970
King IB, Song X, Ma W, Wu JHY, Wang Q, Lemaitre RN, Mukamal KJ, Djoussé L, Biggs ML, Delaney JA, Kizer JR, Siscovick DS, Mozaffarian D. Prospective association of fatty acids in the de novo lipogenesis pathway with risk of type 2 diabetes: the Cardiovascular Health Study 1–5. Am J Clin Nutr. 2015;101(1):153–63. https://doi.org/10.3945/ajcn.114.092601.De.
Lamaziere A, Wolf C, Barbe U, Bausero P, Visioli F. Lipidomics of hepatic lipogenesis inhibition by omega 3 fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2013a;88(2):149–54. https://doi.org/10.1016/j.plefa.2012.12.001.
Lamaziere A, Farabos D, Wolf C, Quinn PJ. The deficit of lipid in cultured cells contrasted with clinical lipidomics. Mol Nutr Food Res. 2013b;57(8):1401–9. https://doi.org/10.1002/mnfr.201200741.
Le Bloc’h J, Leray V, Nazih H, Gauthier O, Serisier S, Magot T, Krempf M, Nguyen P, Ouquerram K. Nicotinic acid accelerates HDL cholesteryl ester turnover in obese insulin-resistant dogs. PLoS One. 2015;10(9):e0136934. https://doi.org/10.1371/journal.pone.0136934.
Lee JJ, Lambert JE, Hovhannisyan Y, Ramos-Roman MA, Trombold JR, Wagner DA, Parks EJ. Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis. Am J Clin Nutr. 2015;101(1):34–43. https://doi.org/10.3945/ajcn.114.092262.
Li K, Brennan L, McNulty BA, Bloomfield JF, Duff DJ, Devlin NFC, Gibney MJ, Flynn A, Walton J, Nugent AP. Plasma fatty acid patterns reflect dietary habits and metabolic health: a cross-sectional study. Molecular Nutr Food Res. 2016;n/a–n/a. https://doi.org/10.1002/mnfr.201500711.
Melin T, Qi C, Nilsson A. Bile but not chylelipoprotein is an important source of arachidonic acid for the rat small intestine. Prostaglandins Leukot Essent Fatty Acids. 1996;55:337–43.
Murata T. Analysis of fatty acid methyl esters by. J Lipid Res. 1978;19:260.
Nilsson A, Hjelte L, Strandvik B. Metabolism of orally fed [3H]-eicosapentaenoic and [14C]-arachidonic acid in essential fatty acid-deficient rats. Scand J Clin Lab Invest. 1996;56(3):219–27.
Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI. Acetate mediates a microbiome-brain-beta-cell axis to promote metabolic syndrome. Nature. 2016;534(7606):213–7. https://doi.org/10.1038/nature18309.
Serrano-Ferrer J, Crendal E, Walther G, Vinet A, Dutheil F, Naughton G, Lesourd B, Chapier R, Courteix D, Obert P. Effects of lifestyle intervention on left ventricular regional myocardial function in metabolic syndrome patients from the RESOLVE randomized trial. Metab Clin Exp. 2016;65(9):1350–60. https://doi.org/10.1016/j.metabol.2016.05.006.
Tenenhaus M. La régression PLS: théorie et pratique. Paris: Editions Technip; 1998.
Thode HC, Smith LA, Finch SJ. Power of tests of normality for detecting scale contaminated normal samples. Commun Stat Simul Comput. 1983;12(6):675–95. https://doi.org/10.1080/03610918308812352.
Acknowledgements
The service de Spectrométrie de Masse (ERL INSERM 1157/UMR7203 Faculté de Médecine Pierre et Marie Curie, Paris, Fr.) has supported the lipidomic GCMS measurements. Applied Lipid Investigations® (http://joomla.aplipid.com/) has supported the statistical investigation of the lipidomics measurements. The trial was supported by Blaise Pascal University—Laboratory of Metabolic Adaptations to Exercise under Physiological and Pathological Conditions and by the thermal baths of Chatel-Guyon and the Omental Thermalia, Chatelguyon, France. Richard Naftalin is thanked for helpful comments on the text.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Farabos, D., Wolf, C., Chapier, R., Lamaziere, A., Quinn, P.J. (2018). An Evaluation of Multivariate Data Analysis Models for Lipidomic Parameters from Patients with Metabolic Syndrome Undergoing Remedial Treatment. In: Wang, X., Wu, D., Shen, H. (eds) Lipidomics in Health & Disease. Translational Bioinformatics, vol 14. Springer, Singapore. https://doi.org/10.1007/978-981-13-0620-4_4
Download citation
DOI: https://doi.org/10.1007/978-981-13-0620-4_4
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-0619-8
Online ISBN: 978-981-13-0620-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)