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Phospholipid and Phospholipidomics in Health and Diseases

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Lipidomics in Health & Disease

Part of the book series: Translational Bioinformatics ((TRBIO,volume 14))

Abstract

Phospholipids (PLs), which are of diverse chemical structures, are not only the major component of the plasma membranes, but also act as signaling mediators for various biological processes and play key roles in energy storage. Cumulative evidence indicates that alterations in composition, distribution, and metabolism of various PLs in cells, tissues, as well as body fluids, have been implicated in various human diseases such as cancer, diabetes, cardiovascular and infectious diseases. The techniques for comprehensive characterization and quantification of PLs (defined here as phospholipidomics) has made profound advances and been rapidly expanded, which not only allows for “visualizing” and understanding the changes of hundreds to thousands of individual PL species, but also facilitates to explore the underlying mechanisms of PLs metabolism and their (dys) regulation in health and disease. Here, we provide an overview of the current state of knowledge with respect to the structural diversity and cellular function of PLs, as well as their implication with various diseases, and the strategies for phospholipidomics analysis and some recent advances.

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Acknowledgements

This work was supported by grants from the National Key R&D Program of China (2018YFA0507801), the National Natural Science Foundation of China (Grants 31670185 and 91640112) and the Stragetic Priority Research Programs of the Chinese Academy of Sciences (XDA12030202).

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  1. Laboratory of Protein and Peptide Pharmaceuticals & Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

    Tanxi Cai & Fuquan Yang

  2. University of Chinese Academy of Sciences, Beijing, China

    Tanxi Cai & Fuquan Yang

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  1. Tanxi Cai
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  2. Fuquan Yang
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Correspondence to Fuquan Yang .

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Editors and Affiliations

  1. Zhongshan Hospital Institute of Clinical Science, Fudan University Shanghai Medical College, Shanghai, China

    Xiangdong Wang

  2. Zhongshan Hospital Institute of Clinical Science, Fudan University Shanghai Medical School, Shanghai, China

    Duojiao Wu

  3. Institutes of Biomedicine, Fudan University, Shanghai, China

    Huali Shen

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Cai, T., Yang, F. (2018). Phospholipid and Phospholipidomics in Health and Diseases. In: Wang, X., Wu, D., Shen, H. (eds) Lipidomics in Health & Disease. Translational Bioinformatics, vol 14. Springer, Singapore. https://doi.org/10.1007/978-981-13-0620-4_11

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