Abstract
The current world is emphasized to create new therapeutic drugs from natural sources to compete the various life-threatening diseases. This investigation has mainly focused to develop prospective metabolite to treat cancer. The bioactive metabolite has been targeted to be produced by a medicinal tree Aegle marmelos (Vilva tree) for anticancer potentiality. The stated medicinal tree secretes several metabolites which have been used extensively in traditional medicine to treat various diseases and disorders. This current research aimed to extract a single bioactive metabolite through preliminary analysis such as antimicrobial and antioxidant assessment against different clinical bacterial and fungal pathogens. The crude metabolites extract from branch sample of Vilva tree explored the maximum activity, so it was taken for purification process by chromatographic techniques. On purification through HPLC analysis, about seven different fractions were eluted, and those were determined for antioxidant and antimicrobial assessment. MF4 fraction explored its maximum activity at minimum concentration for both assessment. This MF4 compound on chemical characterization was found to be 5-acetoxytridecane, a potential compound and it evinced good anti-angiogenic activity through HET-CAM testing which manifested a strong anticancer potentiality.
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Mani, V.M., Soundari, A.J.P.G. (2018). Characterization of a Secondary Metabolite from Aegle marmelos (Vilva Tree) of Western Ghats. In: Kumar, N. (eds) Biotechnological Approaches for Medicinal and Aromatic Plants. Springer, Singapore. https://doi.org/10.1007/978-981-13-0535-1_7
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DOI: https://doi.org/10.1007/978-981-13-0535-1_7
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