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HIV T-Cell Vaccines

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HIV Vaccines and Cure

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1075))

Abstract

Some of the strongest immune correlates of controlled HIV infection include markers related to antiviral T-cell responses, especially responses mediated by CD8+ cytotoxic T lymphocytes (CTL). These observations and lessons learned from other viral infections have motivated the development of T-cell vaccine candidates to HIV in the preventive and especially in the therapeutic setting. While none of the T-cell vaccine concepts tested to date have shown sufficient efficacy, the last few years have seen some advances indicating that strategies activating the cellular adaptive immune response to HIV may present a critical component of an effective therapeutic and possibly preventive HIV vaccine. Some of the important components that a successful T-cell vaccine may need to contain and additional considerations for the design and delivery of such vaccines are discussed in this chapter.

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Authors and Affiliations

  1. Irsicaixa AIDS Research Institute, and Lluita contra la SIDA Foundation, Badalona, Spain

    Beatriz Mothe & Christian Brander

  2. Hospital Germans Trias i Pujol, Badalona, Spain

    Beatriz Mothe

  3. University of Vic-Universitat Central de Catalunya, Barcelona, Spain

    Beatriz Mothe & Christian Brander

  4. ICREA, Pg. Lluís Companys 23, Barcelona, Spain

    Christian Brander

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  1. Beatriz Mothe
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  1. Comprehensive AIDS Research Center, School of Medicine, Tsinghua University, Beijing, China

    Linqi Zhang

  2. The Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, VIC, Australia

    Sharon R. Lewin

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Mothe, B., Brander, C. (2018). HIV T-Cell Vaccines. In: Zhang, L., Lewin, S. (eds) HIV Vaccines and Cure . Advances in Experimental Medicine and Biology, vol 1075. Springer, Singapore. https://doi.org/10.1007/978-981-13-0484-2_2

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