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Gene and Cell Therapy: Biology and Applications pp 57–110Cite as

Nanointerventions for Gene Therapy

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Abstract

Selective silencing of an over-expressed gene or constitutively expressing an under-expressed gene represents an effective strategy to treat diseases at a molecular level. Reprogramming the gene expression has also been found to be an attractive option for regeneration of tissues and organs. However, the potential of gene therapy remains underutilized. This is due to the absence of a mechanism to deliver the oligonucleotide into the target site with high precision and efficiency without compromising its stability. The recent developments witnessed in the realm of nanotechnology have revived interest in gene therapy strategies as the use of nano-dimensional carriers can overcome many of the current limitations. Though viruses were the first nanostructured systems to be explored for gene therapy applications, there has been considerable progress made in the development of non-viral delivery systems for gene therapy. This chapter provides an overview of the advances made in the field of gene delivery and various nanostructured delivery systems that have been reported for therapeutic applications with an emphasis on non-viral vectors.

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Acknowledgement

The authors wish to acknowledge funding towards development of novel gene delivery systems from DBT (BT/PR-11210/NNT/28/421/2008) (UMK), DST’s Indo-Russia collaborative programme (INT/RUS/RSF/P-10) (UMK & VA), Nanomission (SR/NM/PG-16/2007) (UMK) and SASTRA Deemed University (UMK).

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Authors and Affiliations

  1. Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), School of Chemical & Biotechnology, SASTRA University, Thanjavur, Tamil Nadu, India

    K. Uma Maheswari

  2. Limnological Institute, Siberian Branch of the Russian Academy of Sciences, Irkutsk, Russia

    Vadim Annenkov

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  1. K. Uma Maheswari
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  2. Vadim Annenkov
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Correspondence to K. Uma Maheswari .

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Editors and Affiliations

  1. Department of BSBE, IIT-Kanpur, Kanpur, Uttar Pradesh, India

    Giridhara R. Jayandharan

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Uma Maheswari, K., Annenkov, V. (2018). Nanointerventions for Gene Therapy. In: Jayandharan, G. (eds) Gene and Cell Therapy: Biology and Applications. Springer, Singapore. https://doi.org/10.1007/978-981-13-0481-1_3

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