Bioartificial Esophagus: Where Are We Now?

  • Eun-Jae ChungEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1064)


The current treatments for esophageal diseases, such as carcinomas, trauma or congenital malformations, require surgical intervention and esophageal reconstruction using redundant parts of the gastrointestinal tract. However, the use of gastrointestinal segments can cause various surgical morbidities and mortality because additional abdominal surgery may be required at the expense of other anatomic structures. Therefore, tissue engineering using various biomaterial or cell sources has emerged as an alternative strategy of biomimicking the native esophageal tissue that could be implanted as an artificial graft. Although tissue engineering techniques have promise as an effective regenerative strategy, no functional solution currently exists for esophageal reconstruction. Here, we present a review of the progress made in the field of regenerative medicine for esophageal reconstruction from bench to bedside.


Esophagus Tissue engineering Scaffold Decellularized extracellular matrix Synthetic polymer Epithelial cell Smooth muscle cell 



This research was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI16C0362).


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of Otorhinolaryngology-Head and Neck Surgery, College of MedicineSeoul National UniversitySeoulSouth Korea

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