Abstract
Tissue engineering is an appealing research field that involves the replacement and repair of damaged cells and tissues. Scientists and researchers are facing a great challenge to design and develop suitable scaffold materials with biological activities for the applications in tissue regeneration. Among a variety of natural and synthetic materials, biomimetic self-assembling peptides hold great promises as building blocks for fabricating hydrogel scaffolds with three-dimensional (3D) network structures, which could mimic the natural extracellular matrix (ECM). Furthermore, functionalized self-assembling peptides are easily obtained by introducing multiple bioactive peptide motifs derived from naturally occurring proteins. Over the past two decades, many kinds of biomimetic self-assembling peptides have been designed and developed, and these formed peptide hydrogel scaffolds show great potential applications in tissue engineering, such as angiogenesis, bone, cartilage, and nerve regeneration. In this chapter, we have endeavored to do a comprehensive review of biomimetic self-assembling peptides that form nanofiber hydrogel scaffolds. In particular, recent advances of biomimetic self-assembling peptide hydrogel for tissue engineering applications are also highlighted.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Aggeli A, Boden N, Cheng YL, Findlay JB, Knowles PF, Kovatchev P, Turnbull PJ (1996) Peptides modeled on the transmembrane region of the slow voltage-gated IsK potassium channel: structural characterization of peptide assemblies in the beta-strand conformation. Biochemistry 35(50):16213. https://doi.org/10.1021/bi960891g
Aggeli A, Bell M, Boden N, Keen JN, Knowles PF, McLeish TCB, Pitkeathly M, Radford SE (1997a) Responsive gels formed by the spontaneous self-assembly of peptides into polymeric β-sheet tapes. Nature 386:259. https://doi.org/10.1038/386259a0
Aggeli A, Bell M, Boden N, Keen JN, McLeish TCB, Nyrkova I, Radford SE, Semenov A (1997b) Engineering of peptide [small beta]-sheet nanotapes. J Mater Chem 7(7):1135–1145. https://doi.org/10.1039/A701088E
Aggeli A, Bell M, Carrick L, Fishwick C, Harding R, Mawer P, Radford S, Strong A, Boden N (2003) pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases. J Am Chem Soc 125(32):9619. https://doi.org/10.1021/ja021047i
Ai J, Kiasatdolatabadi A, Ebrahimibarough S, Lotfibakhshaiesh N (2013) Polymeric scaffolds in neural tissue engineering: a review. Arch Neurosci 1(1):15–20. https://doi.org/10.5812/archneurosci.9144
Angeloni NL, Bond CW, Tang Y, Harrington DA, Zhang S, Stupp SI, McKenna KE, Podlasek CA (2011) Regeneration of the cavernous nerve by Sonic hedgehog using aligned peptide amphiphile nanofibers. Biomaterials 32(4):1091–1101. https://doi.org/10.1016/j.biomaterials.2010.10.003
Arnold MS, Guler MO, Hersam MC, Stupp SI (2005) Encapsulation of carbon nanotubes by self-assembling peptide amphiphiles. Langmuir 21(10):4705–4709. https://doi.org/10.1021/la0469452
Banwell EF, Abelardo ES, Adams DJ, Birchall MA, Corrigan A, Donald AM, Kirkland M, Serpell LC, Butler MF, Woolfson DN (2009) Rational design and application of responsive alpha-helical peptide hydrogels. Nat Mater 8(7):596–600. https://doi.org/10.1038/nmat2479
Beck K, Brodsky B (1998) Supercoiled protein motifs: the collagen triple-helix and the alpha-helical coiled coil. J Struct Biol 122(1–2):17. https://doi.org/10.1006/jsbi.1998.3965
Bellis SL (2011) Advantages of RGD peptides for directing cell association with biomaterials. Biomaterials 32(18):4205–4210. https://doi.org/10.1016/j.biomaterials.2011.02.029
Berndt P, Fields GB, Tirrell M (1995) Synthetic lipidation of peptides and amino acids: monolayer structure and properties. J Am Chem Soc 117(37):9515–9522. https://doi.org/10.1021/ja00142a019
Brunton PA, Davies RPW, Burke JL, Smith A, Aggeli A, Brookes SJ, Kirkham J (2013) Treatment of early caries lesions using biomimetic self-assembling peptides – a clinical safety trial. Bdj 215:E6. https://doi.org/10.1038/sj.bdj.2013.741
Bull SR, Guler MO, Bras RE, Meade TJ, Stupp SI (2005) Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents. Nano Lett 5(1):1–4. https://doi.org/10.1021/nl0484898
Chen P (2005) Self-assembly of ionic-complementary peptides: a physicochemical viewpoint. Colloid Surf A 261(1–3):3–24. https://doi.org/10.1016/j.colsurfa.2004.12.048
Collier JH, Messersmith PB (2003) Enzymatic modification of self-assembled peptide structures with tissue transglutaminase. Bioconjug Chem 14(4):748–755. https://doi.org/10.1021/bc034017t
Cui HG, Webber MJ, Stupp SI (2010) Self-assembly of peptide amphiphiles: from molecules to nanostructures to biomaterials. Biopolymers 94(1):1–18. https://doi.org/10.1002/bip.21328
Davies RPW, Aggeli A (2011) Self-assembly of amphiphilic β-sheet peptide tapes based on aliphatic side chains. J Pept Sci 17(2):107–114. https://doi.org/10.1002/psc.1335
Davis ME, Motion JPM, Narmoneva DA, Takahashi T, Hakuno D, Kamm RD, Zhang S, Lee RT (2005) Injectable Self-Assembling Peptide Nanofibers Create Intramyocardial Microenvironments for Endothelial Cells. Circulation 111(4):442–450. https://doi.org/10.1161/01.cir.0000153847.47301.80
Dong H, Paramonov SE, Hartgerink JD (2008) Self-assembly of α-helical coiled coil nanofibers. J Am Chem Soc 130(41):13691–13695. https://doi.org/10.1021/ja8037323
Eilken HM, Adams RH (2010) Dynamics of endothelial cell behavior in sprouting angiogenesis. Curr Opin Cell Biol 22(5):617–625. https://doi.org/10.1016/j.ceb.2010.08.010
Eskandari S, Guerin T, Toth I, Stephenson RJ (2017) Recent advances in self-assembled peptides: implications for targeted drug delivery and vaccine engineering. Adv Drug Deliv Rev 110:169–187. https://doi.org/10.1016/j.addr.2016.06.013
Fishwick CWG, Beevers AJ, Carrick LM, Whitehouse CD, Aggeli A, Boden N (2003) Structures of helical β-tapes and twisted ribbons: the role of side-chain interactions on twist and bend behavior. Nano Lett 3(11):1475–1479. https://doi.org/10.1021/nl034095p
Fleming S, Debnath S, Frederix PWJM, Tuttle T, Ulijn RV (2013) Aromatic peptide amphiphiles: significance of the Fmoc moiety. Chem Commun 49(90):10587–10589. https://doi.org/10.1039/c3cc45822a
GarcÃa AE, Sanbonmatsu KY (2002) α-Helical stabilization by side chain shielding of backbone hydrogen bonds. Proc Natl Acad Sci 99(5):2782–2787. https://doi.org/10.1089/ten.2006.12.2215
Garreta E, Genové E, Borrós S, Semino CE (2006) Osteogenic differentiation of mouse embryonic stem cells and mouse embryonic fibroblasts in a three-dimensional self-assembling peptide scaffold. Tissue Eng 12(8):2215–2227
Gelain F, Bottai D, Vescovi A, Zhang S (2006) Designer self-assembling peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures. Plos One 1(1):e119. https://doi.org/10.1371/journal.pone.0000119
Gelain F, Silva D, Caprini A, Taraballi F, Natalello A, Villa O, Nam KT, Zuckermann RN, Doglia SM, Vescovi A (2011) BMHP1-derived self-assembling peptides: hierarchically assembled structures with self-healing propensity and potential for tissue engineering applications. ACS Nano 5(3):1845–1859. https://doi.org/10.1021/nn102663a
Giannoudis PV, Dinopoulos H, Tsiridis E (2005) Bone substitutes: an update. Injury 36(3, Supplement):S20–S27. https://doi.org/10.1016/j.injury.2005.07.029
Gomoll AH, Minas T (2014) The quality of healing: articular cartilage. Wound Repair Regen 22:30–38. https://doi.org/10.1111/wrr.12166
Greenfield MA, Palmer LC, Vernizzi G, de la Cruz MO, Stupp SI (2009) Buckled membranes in mixed-valence ionic amphiphile vesicles. J Am Chem Soc 131(34):12030–12031
Gu X, Ding F, Williams DF (2014) Neural tissue engineering options for peripheral nerve regeneration. Biomaterials 35(24):6143–6156. https://doi.org/10.1016/j.biomaterials.2014.04.064
Guo H, Zhang JM, Xu T, Zhang ZD, Yao JR, Shao ZZ (2013) The robust hydrogel hierarchically assembled from a pH sensitive peptide amphiphile based on silk fibroin. Biomacromolecules 14(8):2733–2738. https://doi.org/10.1021/bm4005645
Habibi N, Kamaly N, Memic A, Shafiee H (2016) Self-assembled peptide-based nanostructures: smart nanomaterials toward targeted drug delivery. Nano Today 11(1):41–60. https://doi.org/10.1016/j.nantod.2016.02.004
Haines LA, Rajagopal K, Ozbas B, Salick DA, Pochan DJ, Schneider JP (2005) Light-activated hydrogel formation via the triggered folding and self-assembly of a designed peptide. J Am Chem Soc 127(48):17025–17029. https://doi.org/10.1021/ja054719o
Hamada K, Hirose M, Yamashita T, Ohgushi H (2008) Spatial distribution of mineralized bone matrix produced by marrow mesenchymal stem cells in self-assembling peptide hydrogel scaffold. J Biomed Mater Res Part A 84A(1):128–136. https://doi.org/10.1002/jbm.a.31439
Hartgerink JD, Beniash E, Stupp SI (2001) Self-assembly and mineralization of peptide-amphiphile nanofibers. Science 294(5547):1684–1688. https://doi.org/10.1126/science.1063187
Hayashi K, Ochiaishino H, Shiga T, Onodera S, Saito A, Shibahara T, Azuma T (2016) Transplantation of human-induced pluripotent stem cells carried by self-assembling peptide nanofiber hydrogel improves bone regeneration in rat calvarial bone defects. BDJ Open 2:15007. https://doi.org/10.1038/bdjopen.2015.7
He B, Yuan X, Jiang D (2014) Molecular self-assembly guides the fabrication of peptide nanofiber scaffolds for nerve repair. RSC Adv 4(45):23610–23621. https://doi.org/10.1039/C4RA01826E
Holmes TC, de Lacalle S, Su X, Liu G, Rich A, Zhang S (2000) Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds. Proc Natl Acad Sci 97(12):6728–6733. https://doi.org/10.1073/pnas.97.12.6728
Horii A, Wang X, Gelain F, Zhang S (2007) Biological designer self-assembling peptide nanofiber scaffolds significantly enhance osteoblast proliferation, differentiation and 3-D migration. PloS One 2(2):e190. https://doi.org/10.1371/journal.pone.0000190
Hsieh PCH, Davis ME, Gannon J, MacGillivray C, Lee RT (2006) Controlled delivery of PDGF-BB for myocardial protection using injectable self-assembling peptide nanofibers. J Clin Invest 116(1):237–248. https://doi.org/10.1172/JCI25878
Huey DJ, Hu JC, Athanasiou KA (2012) Unlike bone, cartilage regeneration remains elusive. Science 338(6109):917–921. https://doi.org/10.1126/science.1222454
Jayawarna V, Ali M, Jowitt TA, Miller AF, Saiani A, Gough JE, Ulijn RV (2006) Nanostructured hydrogels for three-dimensional cell culture through self-assembly of fluorenylmethoxycarbonyl–dipeptides. Adv Mater 18(5):611–614. https://doi.org/10.1002/adma.200501522
Jung JP, Jones JL, Cronier SA, Collier JH (2008) Modulating the mechanical properties of self-assembled peptide hydrogels via native chemical ligation. Biomaterials 29(13):2143–2151. https://doi.org/10.1016/j.biomaterials.2008.01.008
Khademhosseini A, Langer R (2016) A decade of progress in tissue engineering. Nat Protoc 11(10):1775–1781. https://doi.org/10.1038/nprot.2016.123
Kisiday J, Jin M, Kurz B, Hung H, Semino C, Zhang S, Grodzinsky A (2002) Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc Natl Acad Sci 99(15):9996–10001. https://doi.org/10.1073/pnas.142309999
Kisiday JD, Kopesky PW, Evans CH, Grodzinsky AJ, McIlwraith CW, Frisbie DD (2008) Evaluation of adult equine bone marrow- and adipose-derived progenitor cell chondrogenesis in hydrogel cultures. J Orthop Res 26(3):322–331. https://doi.org/10.1002/jor.20508
Kopesky PW, Vanderploeg EJ, Sandy JS, Kurz B, Grodzinsky AJ (2009) Self-assembling peptide hydrogels modulate in vitro chondrogenesis of bovine bone marrow stromal cells. Tissue Eng Part A 16(2):465–477. https://doi.org/10.1089/ten.TEA.2009.0158
Kopesky PW, Vanderploeg EJ, Kisiday JD, Frisbie DD, Sandy JD, Grodzinsky AJ (2010) Controlled delivery of transforming growth factor β1 by self-assembling peptide hydrogels induces chondrogenesis of bone marrow stromal cells and modulates Smad2/3 signaling. Tissue Eng Part A 17(1–2):83–92. https://doi.org/10.1089/ten.tea.2010.0198
Koss KM, Unsworth LD (2016) Neural tissue engineering: bioresponsive nanoscaffolds using engineered self-assembling peptides. Acta Biomater 44:2–15. https://doi.org/10.1016/j.actbio.2016.08.026
Koutsopoulos S (2016) Self-assembling peptide nanofiber hydrogels in tissue engineering and regenerative medicine: progress, design guidelines, and applications. J Biomed Mater Res Part A 104(4):1002–1016. https://doi.org/10.1002/jbm.a.35638
Kumar VA, Wang BK, Kanahara SM (2016) Rational design of fiber forming supramolecular structures. Exp Biol Med 241(9):899–908. https://doi.org/10.1177/1535370216640941
Langer R, Vacanti JP (1993) Tissue Eng Sci 260(5110):920–926. https://doi.org/10.1126/science.8493529
Li WW, Talcott KE, Zhai AW, Kruger EA, Li VW (2005) The role of therapeutic angiogenesis in tissue repair and regeneration. Adv Skin Wound Care 18(9):491–500
Li X, Chen YY, Wang XM, Gao K, Gao YZ, Cao J, Zhang ZL, Lei J, Jin ZY, Wang YN (2017) Image-guided stem cells with functionalized self-assembling peptide nanofibers for treatment of acute myocardial infarction in a mouse model. Am J Transl Res 9(8):3723–3731
Liu X, Wang X, Horii A, Wang X, Qiao L, Zhang S, Cui FZ (2012) In vivo studies on angiogenic activity of two designer self-assembling peptide scaffold hydrogels in the chicken embryo chorioallantoic membrane. Nanoscale 4(8):2720–2727. https://doi.org/10.1039/C2NR00001F
Liu X, Pi B, Wang H, Wang XM (2015) Self-assembling peptide nanofiber hydrogels for central nervous system regeneration. Front Mater Sci 9(1):1–13. https://doi.org/10.1007/s11706-015-0274-z
Loo Y, Zhang S, Hauser CA (2012) From short peptides to nanofibers to macromolecular assemblies in biomedicine. Biotechnol Adv 30(3):593–603. https://doi.org/10.1016/j.biotechadv.2011.10.004
Lu JJ, Sun X, Yin HY, Shen XZ, Yang SH, Wang Y, Jiang WL, Sun Y, Zhao LY, Sun XD, Lu SB, Mikos AG, Peng J, Wang XM (2018) A neurotrophic peptide-functionalized selfassembling peptide nanofiber hydrogel enhances rat sciatic nerve regeneration. Nano Res. https://doi.org/10.1007/s12274-018-2041-9
Lupas AN, Gruber M (2005) The structure of α-helical coiled coils. Adv Protein Chem 70:37–38
Ma PX (2008) Biomimetic materials for tissue engineering. Adv Drug Deliv Rev 60(2):184–198. https://doi.org/10.1016/j.addr.2007.08.041
Mandal D, Nasrolahi SA, Parang K (2014) Self-assembly of peptides to nanostructures. Org Biomol Chem 12(22):3544–3561. https://doi.org/10.1039/C4OB00447G
Mata A, Geng Y, Henrikson KJ, Aparicio C, Stock SR, Satcher RL, Stupp SI (2010) Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix. Biomaterials 31(23):6004–6012. https://doi.org/10.1016/j.biomaterials.2010.04.013
Matson JB, Zha RH, Stupp SI (2011) Peptide self-assembly for crafting functional biological materials. Curr Opin Solid State Mater Sci 15(6):225–235. https://doi.org/10.1016/j.brainresbull.2010.07.001
McGrath AM, Novikova LN, Novikov LN, Wiberg M (2010) BD™ PuraMatrix™ peptide hydrogel seeded with Schwann cells for peripheral nerve regeneration. Brain Res Bull 83(5):207–213
Mehrban N, Abelardo E, Wasmuth A, Hudson KL, Mullen LM, Thomson AR, Birchall MA, Woolfson DN (2014) Assessing cellular response to functionalized alpha-helical peptide hydrogels. Adv Healthc Mater 3(9):1387–1391. https://doi.org/10.1002/adhm.201400065
Meng Q, Yao S, Wang X, Chen Y (2014) RADA16: a self-assembly peptide hydrogel for the application in tissue regeneration. J Biomater Tissue Eng 4(12):1019–1029. https://doi.org/10.2106/JBJS.M.01408
Micklitsch CM, Knerr PJ, Branco MC, Nagarkar R, Pochan DJ, Schneider JP (2011) Zinc-triggered hydrogelation of a self-assembling β-hairpin peptide. Angew Chem 50(7):1577–1579. https://doi.org/10.1002/ange.201006652
Miller RE, Grodzinsky AJ, Vanderploeg EJ, Lee C, Ferris DJ, Barrett MF, Kisiday JD, Frisbie DD (2010) Effect of self-assembling peptide, chondrogenic factors, and bone marrow-derived stromal cells on osteochondral repair. Osteoarthr Cartil 18(12):1608–1619. https://doi.org/10.1016/j.joca.2010.09.004
Miller RE, Grodzinsky AJ, Barrett MF, Hung HH, Frank EH, Werpy NM, Mcilwraith CW, Frisbie DD (2014) Effects of the combination of microfracture and self-assembling peptide filling on the repair of a clinically relevant trochlear defect in an equine model. J Bone Joint Surg Am 96(19):1601
Moradi F, Bahktiari M, Joghataei MT, Nobakht M, Soleimani M, Hasanzadeh G, Fallah A, Zarbakhsh S, Hejazian LB, Shirmohammadi M (2012) BD PuraMatrix peptide hydrogel as a culture system for human fetal Schwann cells in spinal cord regeneration. J Neurosci Res 90(12):2335–2348. https://doi.org/10.1002/jnr.23120
Moutevelis E, Woolfson DN (2009) A periodic table of coiled-coil protein structures. J Mol Biol 385(3):726–732. https://doi.org/10.1016/j.jmb.2008.11.028
Narmoneva DA, Oni O, Sieminski AL, Zhang S, Gertler JP, Kamm RD, Lee RT (2005) Self-assembling short oligopeptides and the promotion of angiogenesis. Biomaterials 26(23):4837–4846. https://doi.org/10.1021/ja028215r
Niece KL, Hartgerink JD, Donners JJ, Stupp SI (2003) Self-assembly combining two bioactive peptide-amphiphile molecules into nanofibers by electrostatic attraction. J Am Chem Soc 125(24):7146–7147
Nune M, Subramanian A, Krishnan UM, Kaimal SS, Sethuraman S (2017) Self-assembling peptide nanostructures on aligned poly (lactide-co-glycolide) nanofibers for the functional regeneration of sciatic nerve. Nanomed Nanotechnol Biol Med 12(3):219–235. https://doi.org/10.2217/nnm-2016-0323
Ogawa Y, Yoshiyama C, Kitaoka T (2012) Helical assembly of azobenzene-conjugated carbohydrate hydrogelators with specific affinity for lectins. Langmuir 28(9):4404–4412. https://doi.org/10.1021/jp075117p
Orbach R, Adler-Abramovich L, Zigerson S, Mironi-Harpaz I, Seliktar D, Gazit E (2009) Self-assembled Fmoc-peptides as a platform for the formation of nanostructures and hydrogels. Biomacromolecules 10(9):2646–2651. https://doi.org/10.1021/bm900584m
Ozbas B, Rajagopal K, Hainesbutterick L, Schneider JP, Pochan DJ (2007) Reversible stiffening transition in β-hairpin hydrogels induced by ion complexation. J Phys Chem B 111(50):13901
Palmer LC, Stupp SI (2008) Molecular self-assembly into one-dimensional nanostructures. Acc Chem Res 41(12):1674–1684. https://doi.org/10.1021/ar8000926
Pandya MJ, Spooner GM, Sunde M, Thorpe JR, Rodger A, Woolfson DN (2000) Sticky-end assembly of a designed peptide fiber provides insight into protein fibrillogenesis. Biochemistry 39(30):8728–8734. https://doi.org/10.1021/bi000246g
Pape HC, Evans A, Kobbe P (2010) Autologous bone graft: properties and techniques. J Orthop Trauma 24:S36–S40. https://doi.org/10.1097/BOT.0b013e3181cec4a1
Pashuck ET, Stupp SI (2010) Direct observation of morphological tranformation from twisted ribbons into helical ribbons. J Am Chem Soc 132(26):8819–8821. https://doi.org/10.1021/ja100613w
Pauling L, Corey RB, Branson HR (1951) The structure of proteins; two hydrogen-bonded helical configurations of the polypeptide chain. P Natl Acad Sci USA 37(4):205–211. https://doi.org/10.1073/pnas.37.4.205
Pérez CMR, Stephanopoulos N, Sur S, Lee SS, Newcomb C, Stupp SI (2015) The powerful functions of peptide-based bioactive matrices for regenerative medicine. Ann Biomed Eng 43(3):501–514. https://doi.org/10.1007/s10439-014-1166-6
Petka WA, Harden JL, McGrath KP, Wirtz D, Tirrell DA (1998) Reversible hydrogels from self-assembling artificial proteins. Science 281(5375):389–392. https://doi.org/10.1126/science.281.5375.389
Pochan DJ, Schneider JP, Kretsinger J, Ozbas B, Rajagopal K, Haines L (2003) Thermally reversible hydrogels via intramolecular folding and consequent self-assembly of a de novo designed peptide. J Am Chem Soc 125(39):11802. https://doi.org/10.1021/ja0353154
Pugliese R, Gelain F (2017) Peptidic biomaterials: from self-assembling to regenerative medicine. Trends Biotechnol 35(2):145. https://doi.org/10.1016/j.tibtech.2016.09.004
Rajagopal K, Lamm MS, Hainesbutterick LA, Pochan DJ, Schneider JP (2009) Tuning the pH responsiveness of beta-hairpin peptide folding, self-assembly, and hydrogel material formation. Biomacromolecules 10(9):2619
Risau W (1997) Mechanisms of angiogenesis. Nature 386(6626):671–674. https://doi.org/10.1021/bm900544e
Robson Marsden H, Kros A (2010) Self-assembly of coiled coils in synthetic biology: inspiration and progress. Angew Chem Int Ed 49(17):2988–3005. https://doi.org/10.1002/anie.200904943
Schneider ‡ DJP, Ozbas B, Rajagopal K, Lisa Pakstis A, Kretsinger J (2002) Responsive hydrogels from the intramolecular folding and self-assembly of a designed peptide. J Am Chem Soc 124(50):15030. https://doi.org/10.1089/107632704323061997
Semino CE, Kasahara J, Hayashi Y, Zhang S (2004) Entrapment of migrating hippocampal neural cells in three-dimensional peptide nanofiber scaffold. Tissue Eng 10(3-4):643–655
Shah RN, Shah NA, Lim MMDR, Hsieh C, Nuber G, Stupp SI (2010) Supramolecular design of self-assembling nanofibers for cartilage regeneration. Proc Natl Acad Sci 107(8):3293–3298
Shin H, Jo S, Mikos AG (2003) Biomimetic materials for tissue engineering. Biomaterials 24(24):4353–4364. https://doi.org/10.1016/S0142-9612(03)00339-9
Silva GA, Czeisler C, Niece KL, Beniash E, Harrington DA, Kessler JA, Stupp SI (2004) Selective differentiation of neural progenitor cells by high-epitope density nanofibers. Science 303(5662):1352–1355. https://doi.org/10.1126/science.1093783
Smith AM, Banwell EF, Edwards WR, Pandya MJ, Woolfson DN (2006) Engineering increased stability into self-assembled protein fibers. Adv Funct Mater 16(8):1022–1030. https://doi.org/10.1002/adfm.200500568
Smith AM, Williams RJ, Tang C, Coppo P, Collins RF, Turner ML, Saiani A, Ulijn RV (2008) Fmoc-Diphenylalanine self assembles to a hydrogel via a novel architecture based on pi-pi interlocked beta-sheets. Adv Mater 20(1):37–41. https://doi.org/10.1002/adma.200701221
Sone ED, Zubarev ER, Stupp SI (2002) Semiconductor nanohelices templated by supramolecular ribbons. Angew Chem Int Ed 41(10):1705–1709. https://doi.org/10.1097/TP.0b013e3181806d9d
Spoerke ED, Anthony SG, Stupp SI (2009) Enzyme directed templating of artificial bone mineral. Adv Mater 21(4):425–430. https://doi.org/10.1002/adma.200802242
Stendahl JC, Wang L-J, Chow LW, Kaufman DB, Stupp SI (2008) Growth factor delivery from self-assembling nanofibers to facilitate islet transplantation. Transplantation 86(3):478
Sun Y, Li W, Wu X, Zhang N, Zhang Y, Ouyang S, Song X, Fang X, Seeram R, Xue W (2016) Functional self-assembling peptide nanofiber hydrogels designed for nerve degeneration. ACS Appl Mater Interfaces 8(3):2348–2359. https://doi.org/10.1021/acsami.5b11473
Sun L, Zheng C, Webster TJ (2017) Self-assembled peptide nanomaterials for biomedical applications: promises and pitfalls. Int J Nanomed 12:73. https://doi.org/10.2147/IJN.S117501
Takumi T (1993) A protein with a single transmembrane domain forms an ion channel. Physiology 8(4):175–178
Takumi T, Ohkubo H, Nakanishi S (1988) Cloning of a membrane protein that induces a slow voltage-gated potassium current. Science 242(4881):1042
Tashiro K-i, Sephel GC, Weeks B, Sasaki M, Martin GR, Kleinman HK, Yamada Y (1989) A synthetic peptide containing the IKVAV sequence from the A chain of laminin mediates cell attachment, migration, and neurite outgrowth. J Biol Chem 264(27):16174–16182
Ulijn RV, Smith AM (2008) Designing peptide based nanomaterials. Chem Soc Rev 37(4):664–675. https://doi.org/10.1039/B609047H
Vacanti JP, Langer R (1999) Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation. Lancet 354:Si32–Si34. https://doi.org/10.1016/S0140-6736(99)90247-7
Walshaw J, Woolfson DN (2001) Socket: a program for identifying and analysing coiled-coil motifs within protein structures. J Mol Biol 307(5):1427–1450. https://doi.org/10.1006/jmbi.2001.4545
Wang X, Horii A, Zhang S (2008) Designer functionalized self-assembling peptide nanofiber scaffolds for growth, migration, and tubulogenesis of human umbilical vein endothelial cells. Soft Matter 4(12):2388–2395
Wang XM, Lin Q, Horii A (2011) Screening of functionalized self-assembling peptide nanofiber scaffolds with angiogenic activity for endothelial cell growth. Prog Nat Sci Mater Int 21(2):111–116. https://doi.org/10.1039/B807155A
Wang X, Pan M, Wen J, Tang Y, Hamilton AD, Li Y, Qian C, Liu Z, Wu W, Guo J (2014) A novel artificial nerve graft for repairing long-distance sciatic nerve defects: a self-assembling peptide nanofiber scaffold-containing poly (lactic-co-glycolic acid) conduit. Neural Regen Res 9(24):2132. https://doi.org/10.4103/1673-5374.147944
Wang TW, Chang KC, Chen LH, Liao SY, Yeh CW, Chuang YJ (2017) Effects of an injectable functionalized self-assembling nanopeptide hydrogel on angiogenesis and neurogenesis for regeneration of the central nervous system. Nanoscale 9(42):16281–16292. https://doi.org/10.1039/C7NR06528K
Webber MJ, Tongers J, Newcomb CJ, Marquardt K-T, Bauersachs J, Losordo DW, Stupp SI (2011) Supramolecular nanostructures that mimic VEGF as a strategy for ischemic tissue repair. Proc Natl Acad Sci 108(33):13438–13443. https://doi.org/10.1073/pnas.1016546108
Whitesides GM, Grzybowski B (2002) Self-assembly at all scales. Science 295(5564):2418–2421. https://doi.org/10.1126/science.1070821
Whitesides GM, Mathias JP, Seto CT (1991) Molecular self-assembly and nanochemistry – a chemical strategy for the synthesis of nanostructures. Science 254(5036):1312–1319. https://doi.org/10.1126/science.1962191
Woolfson DN (2001) Core-directed protein design. Curr Opin Struct Biol 11(4):464–471. https://doi.org/10.1016/S0959-440X(00)00234-7
Woolfson DN (2010) Building fibrous biomaterials from alpha-helical and collagen-like coiled-coil peptides. Pept Sci 94(1):118. https://doi.org/10.1002/bip.21345
Wu G, Pan M, Wang X, Wen J, Cao S, Li Z, Li Y, Qian C, Liu Z, Wu W (2015) Osteogenesis of peripheral blood mesenchymal stem cells in self assembling peptide nanofiber for healing critical size calvarial bony defect. Sci Rep 5. https://doi.org/10.1038/srep16681
Xu FM, Wang HB, Zhao J, Liu XS, Li DD, Chen CJ, Ji J (2013) Chiral packing of cholesteryl group as an effective strategy to get low molecular weight supramolecular hydrogels in the absence of intermolecular hydrogen bond. Macromolecules 46(11):4235–4246. https://doi.org/10.1021/ma400276u
Yanlian Y, Ulung K, Xiumei W, Horii A, Yokoi H, Shuguang Z (2009) Designer self-assembling peptide nanomaterials. Nano Today 4(2):193–210. https://doi.org/10.1016/j.nantod.2009.02.009
Ye Z, Zhang H, Luo H, Wang S, Zhou Q, Du X, Tang C, Chen L, Liu J, Shi YK (2008) Temperature and pH effects on biophysical and morphological properties of self-assembling peptide RADA16-I. J Pept Sci 14(2):152–162. https://doi.org/10.1002/psc.988
Yokoi H, Kinoshita T, Zhang S (2005) Dynamic reassembly of peptide RADA16 nanofiber scaffold. Proc Natl Acad Sci U S A 102(24):8414–8419. https://doi.org/10.1073/pnas.0407843102
Yoshida M, Goto N, Kawaguchi M, Koyama H, Kuroda J, Kitahora T, Iwasaki H, Suzuki S, Kataoka M, Takashi F, Kitajima M (2014) Initial clinical trial of a novel hemostat, TDM-621, in the endoscopic treatments of the gastric tumors. J Gastroenterol Hepatol 29:77–79. https://doi.org/10.1111/jgh.12798
Yu Z, Cai Z, Chen Q, Liu M, Ye L, Ren J, Liao W, Liu S (2016) Engineering [small beta]-sheet peptide assemblies for biomedical applications. Biomater Sci 4(3):365–374. https://doi.org/10.1039/C5BM00472A
Zhan X, Gao M, Jiang Y, Zhang W, Wong WM, Yuan Q, Su H, Kang X, Dai X, Zhang W (2013) Nanofiber scaffolds facilitate functional regeneration of peripheral nerve injury. Nanomed Nanotechnol Biol Med 9(3):305–315. https://doi.org/10.1016/j.nano.2012.08.009
Zhang SG (2003) Fabrication of novel biomaterials through molecular self-assembly. Nat Biotechnol 21(10):1171–1178. https://doi.org/10.1038/nbt874
Zhang SG, Altman M (1999) Peptide self-assembly in functional polymer science and engineering. React Funct Polym 41(1-3):91–102. https://doi.org/10.1016/S1381-5148(99)00031-0
Zhang SG, Holmes T, Lockshin C, Rich A (1993) Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane. P Natl Acad Sci USA 90(8):3334–3338. https://doi.org/10.1073/pnas.90.8.3334
Zhang SG, Lockshin C, Cook R, Rich A (1994) Unusually stable beta-sheet formation in an ionic self-complementary oligopeptide. Biopolymers 34(5):663–672. https://doi.org/10.1002/bip.360340508
Zhang S, Holmes TC, DiPersio CM, Hynes RO, Su X, Rich A (1995) Self-complementary oligopeptide matrices support mammalian cell attachment. Biomaterials 16(18):1385–1393. https://doi.org/10.1016/0142-9612(95)96874-Y
Zhang SG, Gelain F, Zhao XJ (2005) Designer self-assembling peptide nanofiber scaffolds for 3D tissue cell cultures. Semin Cancer Biol 15(5):413–420. https://doi.org/10.1016/j.semcancer.2005.05.007
Zhang JM, Hao RW, Huang L, Yao JR, Chen X, Shao ZZ (2011) Self-assembly of a peptide amphiphile based on hydrolysed Bombyx mori silk fibroin. Chem Commun 47(37):10296–10298. https://doi.org/10.1039/c1cc12633d
Zhou A, Chen S, He B, Zhao W, Chen X, Jiang D (2016) Controlled release of TGF-beta 1 from RADA self-assembling peptide hydrogel scaffolds. Drug Des Devel Ther 10:3043–3051. https://doi.org/10.2147/DDDT.S109545
Ziv G, Haran G, Thirumalai D (2005) Ribosome exit tunnel can entropically stabilize α-helices. P Natl Acad Sci USA 102(52):18956–18961. https://doi.org/10.1073/pnas.0508234102
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Lu, J., Wang, X. (2018). Biomimetic Self-Assembling Peptide Hydrogels for Tissue Engineering Applications. In: Noh, I. (eds) Biomimetic Medical Materials. Advances in Experimental Medicine and Biology, vol 1064. Springer, Singapore. https://doi.org/10.1007/978-981-13-0445-3_18
Download citation
DOI: https://doi.org/10.1007/978-981-13-0445-3_18
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-0444-6
Online ISBN: 978-981-13-0445-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)