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Fibrin-Based Biomaterial Applications in Tissue Engineering and Regenerative Medicine

  • Chan Ho Park
  • Kyung Mi WooEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1064)

Abstract

The fibrin matrix is fundamentally formed by the polymerization of fibrinogen and thrombin in blood plasma. It is a natural biopolymeric material to widely investigate for various tissue regenerations due to good biocompatibility, rapid biodegradability, and easy fabrication. In particular, the conjugated bioactive molecules with fibrinogen can promote tissue morphogenesis or maturation after cell adhesion on the matrices, migration, proliferation, or differentiation. Using these physiological properties with cell-material interactions, the fibrin matrices have been utilized in tissue engineering applications such as skin tissue, cardiovascular tissue, musculoskeletal tissue, or nerve tissue in preclinical and clinical situations. This chapter demonstrates the fibrin material and its tissue engineering applications as the therapeutic strategies.

Keywords

Fibrin Biopolymeric mateirals Tissue engineering 

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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of Dental Biomaterials, School of DentistryKyungpook National UniversityDaeguSouth Korea
  2. 2.Department of Pharmacology & Dental Therapeutics, Dental Research Institute and BK21 Program, School of DentistrySeoul National UniversitySeoulSouth Korea

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