ROS-Responsive Biomaterial Design for Medical Applications

  • Jung Bok Lee
  • Young Min Shin
  • Won Shik Kim
  • Seo Yeon Kim
  • Hak-Joon SungEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1064)


Stimuli-responsive biomaterials undergo significant alterations in material structure and property in response to changes of local environmental factors (e.g. pH, temperature, enzyme activation, and water absorption). In particular, reactive oxygen species (ROS) is considered as a major stimulus because over-production of ROS involves most types of major pathogenesis. The application of ROS-responsive biomaterials requires suitable material designs to program user-defined changes of their structure and property in response to a sudden change in the local ROS level. This chapter summarizes the progress in designing and applying major types of ROS-responsive biomaterials within the past 10 years.


Biomaterials Smart function Stimuli-responsive Reactive oxygen species Pathogenesis 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Jung Bok Lee
    • 1
  • Young Min Shin
    • 1
  • Won Shik Kim
    • 2
  • Seo Yeon Kim
    • 1
  • Hak-Joon Sung
    • 1
    Email author
  1. 1.Department of Biomedical ScienceYonsei University College of MedicineSeoulSouth Korea
  2. 2.Department of OtorhinolaryngologyYonsei University College of MedicineSeoulSouth Korea

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