Abstract
S. miltiorrhiza (Lamiaceae) finds wide use in traditional Chinese medicine and is popularly known as red sage. The Chinese name of the medicinal plant is danshen. The plant is native to China and Japan. The roots are used in medicine.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Brunetti G, Serra S, Vacca G, Lobina C, Morazzoni P, Bombardelli E, Colombo G, Gessa GL, Carai MA. IDN 5082, a standardized extract of Salvia miltiorrhiza, delays acquisition of alcohol drinking behavior in rats. J Ethnopharmacol. 2003;85:93–7.
Chang HM, Chui KY, Tan FW, Yang Y, Zhong ZP, Lee CM, Sham HL, Wong HN. Structure-activity relationship of miltirone, an active central benzodiazepine receptor ligand isolated from Salvia miltiorrhiza Bunge (Danshen). J Med Chem. 1991;34:1675–92.
Colombo G, Serra S, Vacca G, Orrù A, Maccioni P, Morazzoni P, Bombardelli E, Riva A, Gessa GL, Carai MA. Identification of miltirone as active ingredient of Salvia miltiorrhiza responsible for the reducing effect of root extracts on alcohol intake in rats. Alcohol Clin Exp Res. 2006;30:754–62.
Hayashi T, Kakisawa H, Hsu H-Y, Chen YP. The structure of miltirone, a new diterpenoid quinine. J Chem Soc D Chem Commun. 1971;24:1585–92.
Jiang M, Wang XY, Zhou WY, Li J, Wang J, Guo LP. Cerebral protection of salvianolic acid A by the inhibition of granulocyte adherence. Am J Chin Med. 2011;39:111–20.
Koo BS, Kwon TS, Kim CH. Salviae miltiorrhizae radix inhibits superoxide generation by activated rat microglias and mimics the action of amphetamine on in vitro rat striatal dopamine release. Neurochem Res. 2004;29:1837–45.
Kuang P, Tao Y, Tian Y. Radix Salviae miltiorrhizae treatment results in decreased lipid peroxidation in reperfusion injury. J Tradit Chin Med. 1996a;16:138–42.
Kuang P, Tao Y, Tian Y. Effect of radix Salviae miltiorrhizae on nitric oxide in cerebral ischemic-reperfusion injury. J Tradit Chin Med. 1996b;16:224–7.
Lee CM, Wong HN, Chui KY, Choang TF, Hon PM, Chang HM. Miltirone, a central benzodiazepine receptor partial agonist from a Chinese medicinal herb Salvia miltiorrhiza. Neurosci Lett. 1991;127:237–41.
Li Q, Han LP, Li ZH, Zhang JT, Tang MK. Salvianolic acid B alleviate the disruption of blood-brain barrier in rats after cerebral ischemia-reperfusion by inhibiting MAPK pathway. Yao Xue Xue Bao. 2010;45:1485–90.
Lian-Niang L, Rui T, Wei-Ming C. Salvianolic Acid A, a New Depside from Roots of Salvia miltiorrhiza. Planta Med. 1984;50:227–8.
Lo CJ, Lin JG, Kuo JS, Chiang SY, Chen SC, Liao ET, Hsieh CL. Effect of Salvia miltiorrhiza Bunge on cerebral infarct in ischemia-reperfusion injured rats. Am J Chin Med. 2003;31:191–200.
Mo Z, Zheng Y, Pan Z, Liang R. Protective effect and mechanism of Salvia miltiorrhiza on cerebral ischemia reperfusion injury in rats. Chin Herb Pharmacol Clin. 1998;14:24–6.
Mostallino MC, Mascia MP, Pisu MG, Busonero F, Talani G, Biggio G. Inhibition by miltirone of up-regulation of GABAA receptor alpha4 subunit mRNA by ethanol withdrawal in hippocampal neurons. Eur J Pharmacol. 2004;494:83–90.
Ozarowski M, Mikolajczak PL, Piasecka A, Kujawski R, Bartkowiak-Wieczorek J, Bogacz A, Szulc M, Kaminska E, Kujawska M, Gryszczynska A, Kachlicki P, Buchwald W, Klejewski A, Seremak-Mrozikiewicz A. Effect of Salvia miltiorrhiza root extract on brain acetylcholinesterase and butyrylcholinesterase activities, their mRNA levels and memory evaluation in rats. Physiol Behav. 2017;173:223–30.
Ren B, Zhang YX, Zhou HX, Sun FW, Zhang ZF, Wei Z, Zhang CY, Si DW. Tanshinone IIA prevents the loss of nigrostriatal dopaminergic neurons by inhibiting NADPH oxidase and iNOS in the MPTP model of Parkinson’s disease. J Neurol Sci. 2015;348:142–52.
Tang C, Xue H, Bai C, Fu R, Wu A. The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats. Phytomedicine. 2010;17:1145–9.
Tu Q, Wang R, Ding B, Zhong W, Cao H. Protective and antioxidant effect of Danshen polysaccharides on cerebral ischemia/reperfusion injury in rats. Int J Biol Macromol. 2013;60:268–71.
Wang S, Jing H, Yang H, Liu Z, Guo H, Chai L, Hu L. Tanshinone I selectively suppresses pro-inflammatory genes expression in activated microglia and prevents nigrostriatal dopaminergic neurodegeneration in a mouse model of Parkinson’s disease. J Ethnopharmacol. 2015;164:247–55.
Wong KK, Ho MT, Lin HQ, Lau KF, Rudd JA, Chung RC, Fung KP, Shaw PC, Wan DC. Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task. Planta Med. 2010a;76:228–34.
Wong KK, Ngo JC, Liu S, Lin HQ, Hu C, Shaw PC, Wan DC. Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis. Chem Biol Interact. 2010b;187:335–9.
Yu XY, Lin SG, Zhou ZW, Chen X, Liang J, Duan W, Yu XQ, Wen JY, Chowbay B, Li CG, Sheu FS, Chan E, Zhou SF. Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats. Neurosci Lett. 2007;417:261–5.
Yu XQ, Xue CC, Zhou ZW, Li CG, Zhou SF. Tanshinone IIB, a primary active constituent from Salvia miltiorrhiza, exerts neuroprotective effect via inhibition of neuronal apoptosis in vitro. Phytother Res. 2008;22:846–50.
Zhong J, Tang MK, Zhang Y, Xu QP, Zhang JT. Effect of salvianolic acid B on neural cells damage and neurogenesis after brain ischemia-reperfusion in rats. Yao Xue Xue Bao. 2007;42:716–21.
Zhou L, Zuo Z, Chow MS. Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J Clin Pharmacol. 2005;45:1345–59.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Saroya, A.S., Singh, J. (2018). Neuropharmacology of Salvia miltiorrhiza Bunge (Danshen). In: Pharmacotherapeutic Potential of Natural Products in Neurological Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-13-0289-3_15
Download citation
DOI: https://doi.org/10.1007/978-981-13-0289-3_15
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-0288-6
Online ISBN: 978-981-13-0289-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)