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Molecular Mechanisms of Nanotoxicity Formation

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Nanotoxicology in Caenorhabditis elegans

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Abstract

Based on the conserved property of molecular events, signal transduction pathways, epigenetic marks, and the homology of approximately 45% genes in Caenorhabditis elegans to human genome, C. elegans has the important potentials for the elucidation of underlying molecular mechanisms of toxicity induced by engineered nanomaterials (ENMs). We here introduced the functions and the underlying molecular mechanisms of some important signaling pathways in the regulation of nanotoxicity formation, and these signaling pathways mainly include apoptosis signaling pathway, DNA damage signaling pathway, MAPK signaling pathways, insulin signaling pathway, innate immune response signaling pathway, Wnt signaling pathway, TGF-beta signaling pathway, developmental timing control-related signals, and neurotransmission-related signals. We also systematically introduced the functions and the underlying molecular basis for microRNAs and long noncoding RNAs in the regulation of nanotoxicity formation based on the clues from the omics study performed in nematodes.

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Authors and Affiliations

  1. Medical School, Southeast University, Nanjing, Jiangsu, China

    Dayong Wang

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  1. Dayong Wang
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Wang, D. (2018). Molecular Mechanisms of Nanotoxicity Formation. In: Nanotoxicology in Caenorhabditis elegans. Springer, Singapore. https://doi.org/10.1007/978-981-13-0233-6_7

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