Abstract
Biofilms are the major concerns to the researchers, due to their universal distribution among prokaryotes and involvement in antibiotic drug resistance towards conventional drugs. It led the bacteria to become up to 1000 times resistant towards antibiotics. Therefore, diverse types of anti-biofilm agents are continuously designed to target them namely (phyto) chemicals, peptides, enzymes, biosurfactants, microbial extracts, nanoparticles, and many more. Antibiofilm peptides have demonstrated high potential in targeting biofilm due to their low toxicity, and off-target effects. These peptides are experimentally validated to disrupt most of the biofilms developed on medical devices like catheters, stents, dentures, etc. implicated in nosocomial infections by ESKAPE pathogens. However, one of the important reasons for the peptides, to emerge as a new hope against biofilms, is their wide mode of action against different stages and microbial species. In the present chapter, we are focusing to explore various aspects of this important class of antibiofilm therapeutics.
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Rajput, A., Kumar, M. (2018). Anti-biofilm Peptides: A New Class of Quorum Quenchers and Their Prospective Therapeutic Applications. In: Kalia, V. (eds) Biotechnological Applications of Quorum Sensing Inhibitors. Springer, Singapore. https://doi.org/10.1007/978-981-10-9026-4_5
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