Abstract
Pathogenic Pseudomonas species produce virulence elements and form biofilm through quorum sensing (QS) system. Clinical infections caused by Pseudomonas aeruginosa are becoming increasingly tough to treat on account of wide spread drug resistance. The drugs have lost their efficacy due to the virulence elements and biofilms, which are responsible for increased severity of the infection. The search for novel drugs has increased and novel modes of action against Gram-negative pathogenic bacteria are been much more of important. Plants secondary metabolites are widely used for treating the many bacterial diseases. Plant-derived anti-QS and anti-biofilm compounds that do not negatively affect the growth of the bacterial cells, but rather attenuates the QS controlled virulence factors, that might allow the host defense to act more effectively to washout the P. aeruginosa infection. In this review mainly focus on overview of pathogenicity, QS controlled virulence factors and biofilm formation of P. aeruginosa infection. This review describes a brief account of QS inhibitors and anti-biofilm compounds, which exhibit alternative medicine possible for treating drug resistant P. aeruginosa.
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Abbreviations
- AHL:
-
N-acyl homoserine lactone
- AIDS:
-
Acquired immune diseases
- AIs:
-
Autoinducers
- C12 – HSL:
-
N-dodecanoyl-homoserine lactone
- C4-HSL:
-
N-butyrl –L-homosrine lactone
- CNS:
-
Cerebrospinal fluid
- CO2 :
-
Carbon dioxide
- 3-Oxo-C12-HSL:
-
N-3-oxo-dodecanoyl-homoserine lactone
- EPS:
-
Exopolymeric substance
- EVD:
-
External ventricular drainage
- HCN:
-
Hydrogen cyanide
- ICU:
-
Intensive care unit
- QS:
-
Quorum sensing
- QSI:
-
Quorum sensing inhibitor
- SAM:
-
S-adenosyl methione
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Sankar Ganesh, P., Ravishankar Rai, V. (2018). Alternative Strategies to Regulate Quorum Sensing and Biofilm Formation of Pathogenic Pseudomonas by Quorum Sensing Inhibitors of Diverse Origins. In: Kalia, V. (eds) Biotechnological Applications of Quorum Sensing Inhibitors. Springer, Singapore. https://doi.org/10.1007/978-981-10-9026-4_3
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