Abstract
The mouse is the animal most commonly used in biomedical research. In particular, recent advances in molecular and genetic techniques require new experimental approaches for the study of pathologies involving the vestibulo-ocular reflex (VOR) and other visual, otologic, or cerebellar-related impairments in this laboratory animal. For this, we have developed a video-oculographic recording system that enables analyzing several parameters of the VOR. For quantification and comparative purposes, we have studied the VOR in hypoxic and control mice submitted to 5000 m and 7000 m of simulated altitude in a hypobaric chamber. VOR gain and phase, and the cephalic impulse, were checked in experimental mice. Results indicate an increased VOR gain, from 0.1 Hz to 0.6 Hz, and an impaired VOR performance, in hypoxic mice. In conclusion, the setup reported here for vestibular stimulation provides a video-oculographic recording system suitable for the study of the VOR in mice and delivers enough quantitative data to determine specific impairments, as in the case of acute hypobaric hypoxia.
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López-Ramos, J.C., Cebrián, A.B.G., Delgado-García, J.M. (2018). Application of Video-Oculography for the Analysis of the Vestibulo-Ocular Reflex in Acute Hypoxic Mice. In: Delgado-García, J., Pan, X., Sánchez-Campusano, R., Wang, R. (eds) Advances in Cognitive Neurodynamics (VI). Advances in Cognitive Neurodynamics. Springer, Singapore. https://doi.org/10.1007/978-981-10-8854-4_27
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DOI: https://doi.org/10.1007/978-981-10-8854-4_27
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