Human Mutants

Abstract

Mutations of human prion protein will cause a series of prion diseases to humans such as the ordinary Creutzfeldt-Jakob Disease, the familial Creutzfeldt-Jakob disease, the sporadic Creutzfeldt-Jakob Disease, the Gerstmann-Straussler-Scheinker syndrome, the Fatal Familial Insomnia. This Chapter does MD studies on all mutants of human prion protein known by now. They include the 226*-truncated (PDB entry 5L6R), the R220K mutant (PDB entries 1E1U/W), the E219K-M129 mutant (PDB entry 2LFT), the Q212P-V129 mutant (PDB entry 2KUN), the V210I-M129 mutant (PDB entries 2LEJ/V1), the V209M-M129 mutant (PDB entry 2M8T), the E200K mutant (PDB entries 1FKC/O7), the F198S-M129 mutant (PDB entry 3HES), the F198S-V129 mutant (PDB entry 3HER), the D178N-M129 mutant (PDB entry 3HEQ), the D178N-V129 mutant (PDB entry 3HJX), the D178N mutant (PDB entry 2K1D), the S170N mutant (PDB entries 1E1P/S), the M166C/E221C mutants (PDB entry 1H0L), the M166V mutant (PDB entries 1E1G/J), the V129 mutant (PDB entry 3HAK), Through our MD studies we try to seek some structural bioinformatics to understand or treat prion diseases for humans.