Abstract
All reactions were carried out in dried glassware under an argon atmosphere and at room temperature (22 °C) unless aqueous conditions were used or unless otherwise specified. Reactions undertaken at −78 °C utilized a bath of dry ice and acetone. Reactions carried out at 0 °C employed a bath of water and ice. Anhydrous THF, CH2Cl2, MeCN, DMF, toluene and MeOH were obtained using a PureSolv® solvent purification system with water detectable only in low ppm levels. Reactions were monitored by thin layer chromatography (TLC) on aluminium backed silica plates (Merck Silica Gel 60 F254). Visualisation of TLC plates was undertaken with an ultraviolet (UV) light at λ = 254 nm and staining with solutions of vanillin, ninhydrin, phosphomolybdic acid (PMA), potassium permanganate or sulfuric acid, followed by exposure of the stained plates to heat. Silica flash column chromatography (Merck Silica Gel 60 40–63 μm) was undertaken to purify crude reaction mixtures using solvents as specified.
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Giltrap, A. (2018). Experimental. In: Total Synthesis of Natural Products with Antimicrobial Activity. Springer Theses. Springer, Singapore. https://doi.org/10.1007/978-981-10-8806-3_5
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