Anti-epileptic Action of Thymoquinone



A number of studies have been carried out to establish the anti-epileptic activity of N. sativa. Thymoquinone (TQ) is found in volatile oil of the plant and is considered the main constituent responsible for its anti-epileptic effect. Mechanism of action of TQ on seizures is not completely established; however some researchers believe that it produces anticonvulsant effect by interacting with gamma-aminobutyric acid (GABA). Some researchers in their study found that the co-administration of TQ and some known anti-epileptic drugs led to the potentiation of their anti-epileptic effect and suppressed their adverse effects.


Thymoquinone (TQ) Anticonvulsant Activity Anticonvulsant Effects Calmodulin-dependent Protein Kinase II (CaMKII) International League Against Epilepsy (ILAE) 
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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of Pharmaceutical Chemistry and PharmacognosyUnaizah College of Pharmacy, Qassim UniversityUnaizahKingdom of Saudi Arabia

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