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Anti-epileptic Action of Thymoquinone

Chapter

Abstract

A number of studies have been carried out to establish the anti-epileptic activity of N. sativa. Thymoquinone (TQ) is found in volatile oil of the plant and is considered the main constituent responsible for its anti-epileptic effect. Mechanism of action of TQ on seizures is not completely established; however some researchers believe that it produces anticonvulsant effect by interacting with gamma-aminobutyric acid (GABA). Some researchers in their study found that the co-administration of TQ and some known anti-epileptic drugs led to the potentiation of their anti-epileptic effect and suppressed their adverse effects.

Keywords

Thymoquinone (TQ) Anticonvulsant Activity Anticonvulsant Effects Calmodulin-dependent Protein Kinase II (CaMKII) International League Against Epilepsy (ILAE) 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of Pharmaceutical Chemistry and PharmacognosyUnaizah College of Pharmacy, Qassim UniversityUnaizahKingdom of Saudi Arabia

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