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Antioxidant and Anti-inflammatory Action of Thymoquinone

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Molecular and Therapeutic actions of Thymoquinone

Abstract

Antioxidant and anti-inflammatory action of thymoquinone (TQ) may be utilized in the treatment of inflammatory diseases such as prostatitis, neuropsychiatric, mucositis, etc. TQ has been shown to have potential as a supplement co-drug against methotrexate-induced intestinal and nephrotoxicity in cancer chemotherapy. Besides, it suppresses the characteristics of airway inflammation by reducing the production of inflammatory mediators such as 5-lipoxygenase, leukotriene, and eosinophils. NF-κB is a transcription factor that plays a role in inflammatory diseases. Suppression of NF-κB by TQ has a role in its anti-inflammatory actions. Subsequently, inhibition of inflammatory cytokines and mediators which are key components in the process of inflammation is exploited to reduce inflammation and damage. TQ inhibits LPS-induced IL-1β, ΙL-6, and ΙL-12p40/70 production, which suggests the potential of TQ in suppressing pro-inflammatory cytokines. It ameliorates sodium nitrite-induced elevation of NFκB and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) in testicular.

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Authors and Affiliations

  1. College of Applied Medical Sciences, Qassim University, Buraidah, Saudi Arabia

    Arif Khan

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  1. Arif Khan
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  1. Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

    Hina Younus

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Khan, A. (2018). Antioxidant and Anti-inflammatory Action of Thymoquinone. In: Younus, H. (eds) Molecular and Therapeutic actions of Thymoquinone. Springer, Singapore. https://doi.org/10.1007/978-981-10-8800-1_4

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