Anticancer Action of Thymoquinone



Thymoquinone (TQ) is a biologically active compound found in the Nigella sativa and extensively studied over the decades for its implications in diseases management without promoting the adverse side effects. An extensive number of researches have been performed to evaluate the efficacy of TQ in killing of cancer cells through modulating several biological activities, which play a vital role in the pathogenesis of cancer. Moreover, TQ shows an important role in the induction of apoptosis as well as cell cycle arrest in cancerous cells through the upregulation of PTEN gene and cyclin-dependent kinase inhibitor. A novel molecular target of TQ against numerous cancerous cells or inhibition of cancer growth is the modulation of protein kinase, nuclear factor kappa B, angiogenesis and tumorigenesis. Although numerous studies based on animal model and laboratory research have been performed to assess the potentiality of TQ in cancer prevention, chemopreventive role of TQ in humans is still unexplored. However, detailed and appropriate studies are needed to authenticate the role of TQ as a future drug therapy in the management of cancer.


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.College of Applied Medical SciencesQassim UniversityBuraidahSaudi Arabia

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