Antidiabetic Action of Thymoquinone
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Diabetes has become the most common metabolic disease worldwide. Hyperglycemia has a key role in the diseases associated with diabetic complications. N. sativa seeds possess antidiabetic and hypoglycemic activity. It is the thymoquinone (TQ) content of these seeds that is the main constituent associated with the antidiabetic activity of the plant. TQ is quite effective in protecting the β-cells from damage due to oxidative stress and decreases hepatic gluconeogenesis. It prevents insulin resistance, protein glycation, and diabetic nephropathy and has many other antidiabetic properties. The antioxidant, cytoprotective and immunomodulating actions of TQ and N. sativa, may be pharmacologically relevant in curing diabetes and its complications.
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