In this introductory chapter, we will establish an understanding that thymoquinone (TQ) which is a principle component of the seeds (volatile oil portion) of Nigella sativa (black cumin) is a developing natural compound with a variety of therapeutic actions. A short introduction to the history of using black cumin seeds and TQ for therapeutic purposes is provided. The constituents of Nigella sativa seeds are briefly mentioned. Next, the recent advances in TQ research, with special emphasis on its therapeutic actions, are explained. Furthermore, an overview on the entire book and what can be found in each chapter are provided.


  1. Ahmad SS, Najmi AK, Kaundal M, Akhtar M (2017) Gastroprotective effect of Thymoquinone on water immersion restraint stress induced ulceration in rats. Drug Res (Stuttg) 67:366. CrossRefGoogle Scholar
  2. AlAttas SA, Zahran FM, Turkistany SA (2016) Nigella sativa and its active constituent thymoquinone in oral health. Saudi Med J 37:235–244CrossRefGoogle Scholar
  3. Al-Bukhari MI, Al-Bukhari S (1976) The collection of authentic sayings of Prophet Mohammad (peace be upon him), division 71 on medicine, 2nd edn. Hilal Yayinlari, AnkaraGoogle Scholar
  4. Ali BH, Blunden G (2003) Pharmacological and toxicological properties of Nigella sativa. Phytother Res 17:299–305CrossRefGoogle Scholar
  5. Bhatti IU, Rehman FU, Khan M, Marwat S (2009) Effect of prophetic medicine kalonji (Nigella sativa L.) on lipid profile of human beings. An in vivo approach. World Appl Sci J 6:1053–1057Google Scholar
  6. Dajani EZ, Shawan TG, Dajani NE (2016) Overview of the preclinical pharmacological properties of Nigella sativa (black seeds): a complementary drug with historical and clinical significance. J Physiol Pharmacol 67:801–817PubMedGoogle Scholar
  7. El-Far AH (2015) Thymoquinone anticancer discovery: possible mechanisms. Curr Drug Discov Technol 12:80–89CrossRefGoogle Scholar
  8. Gholamnezhad Z, Havakhah S, Boskabady MH (2016) Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: a review. J Ethnopharmacol 190:372–386CrossRefGoogle Scholar
  9. Hayatdavoudi P, Khajavi Rad A, Rajaei Z, Hadjzadeh M (2016) Renal injury, nephrolithiasis and Nigella sativa: a mini review. Avicenna J Phytomed 6:1–8CrossRefGoogle Scholar
  10. Jalili C, Salahshoor MR, Hoseini M, Roshankhah S, Sohrabi M, Shabanizadeh A (2017) Protective effect of Thymoquinone against morphine injuries to kidneys of mice. Iran J Kidney Dis 11:142–150PubMedGoogle Scholar
  11. Khader M, Eckl PM (2014) Thymoquinone: an emerging natural drug with a wide range of medical applications. Iran J Basic Med Sci 17:950–957PubMedPubMedCentralGoogle Scholar
  12. Khan MA, Anwar S, Aljarbou AN, Al-Orainy M, Aldebasi YH, Islam S, Younus H (2014) Protective effect of thymoquinone on glucose or methylglyoxal-induced glycation of superoxide dismutase. Int J Biol Macromol 65:16–20CrossRefGoogle Scholar
  13. Kouidhi B, Zmantar T, Jrah H, Souiden Y, Chaieb K, Mahdouani K et al (2011) Antibacterial and resistance-modifying activities of thymoquinone against oral pathogens. Ann Clin Microbiol Antimicrob 10:29CrossRefGoogle Scholar
  14. Laskar AA, Khan MA, Rahmani AH, Fatima S, Younus H (2016) Thymoquinone, an active constituent of Nigella sativa seeds, binds with bilirubin and protects mice from hyperbilirubinemia and cyclophosphamide-induced hepatotoxicity. Biochimie 127:205–213CrossRefGoogle Scholar
  15. Luetjohann S (1998) The healing power of black cumin. Lotus Light, Silver LakeGoogle Scholar
  16. Majdalawieh AF, Fayyad MW (2015) Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: a comprehensive review. Int Immunopharmacol 28:295–304CrossRefGoogle Scholar
  17. Nasir A, Siddiqui MY, Mohsin M (2014) Therapeutic uses of Shoneez (Nigella sativa Linn.) mentioned in Unani system of medicine – a review. Int J Pharm Phytopharmaco Res 4:47–49Google Scholar
  18. Norsharina I, Maznah I, Aied A-A, Ghanya A-N (2011) Thymoquinone rich fraction from Nigella sativa and thymoquinone are cytotoxic towards colon and leukemic carcinoma cell lines. J Medicinal Plants Res 5:3359–3366Google Scholar
  19. Rahmani AH, Alzohairy MA, Khan MA, Aly SM (2015) Nigella Sativa and its active constituents thymoquinone shows pivotal role in the diseases prevention and treatment. Asian J Pharm Clin Res 8:48–53Google Scholar
  20. Randhawa MA, Alghamdi MS (2011) Anti-cancer activity of Nigella sativa (black seed)—a review. Am J Chin Med 39:1075–1091CrossRefGoogle Scholar
  21. Randhawa MA, Alenazy AK, Alrowaili MG, Basha J (2016) An active principle of Nigella sativa L., thymoquinone, showing significant antimicrobial activity against anaerobic bacteria. J Intercult Ethnopharmacol 6:97–101CrossRefGoogle Scholar
  22. Sahak MKA, Kabir N, Abbas G, Draman S, Hashim NH, Adli DSH (2016) The role of Nigella sativa and its active constituents in learning and memory. Evid Based Complement Alternat Med 2016, Article ID 6075679, 6 pGoogle Scholar
  23. Shafiq H, Ahmad A, Masud T, Kaleem M (2014) Cardio-protective and anti-cancer therapeutic potential of Nigella sativa. Iran J Basic Med Sci 17:967–979PubMedPubMedCentralGoogle Scholar
  24. Ullah I, Badshah H, Naseer MI, Lee HY, Kim MO (2015) Thymoquinone and vitamin C attenuates pentylenetetrazole-induced seizures via activation of GABAB1 receptor in adult rats cortex and hippocampus. NeuroMolecular Med 17:35–46CrossRefGoogle Scholar
  25. Ullah R, Rehman A, Zafeer MF, Rehman L, Khan YA, Khan MA, Khan SN, Khan AU, Abidi SM (2017) Anthelmintic potential of thymoquinone and curcumin on Fasciola gigantica. PLoS One 12:e0171267CrossRefGoogle Scholar
  26. Younus H, Anwar S (2016) Prevention of non-enzymatic glycosylation (glycation): implication in the treatment of diabetic complication. Int J Health Sci 10:261–277Google Scholar

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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Interdisciplinary Biotechnology UnitAligarh Muslim UniversityAligarhIndia

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