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Pharmacogenetic Study in Asthma

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Genomic Approach to Asthma

Part of the book series: Translational Bioinformatics ((TRBIO,volume 12))

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Abstract

Asthma could be viewed as a complex multifactor genetic disease associated with multiple genes. For clinical asthma patients with similar phenotypes, the same treatment can cause very different reactions. Many studies strongly suggest that genetic factors significantly contribute to the clinical outcomes of interindividual pharmacological treatment. To reveal the genetic differences in drug response and drug behavior, pharmacogenomics was developed and expanded to explain the response of drug treatment with acquisition and inheritance factors through the systematic examination of individual variability gene. The pharmacogenetics goal of asthma is to personalize asthma pharmacotherapy and reduce the asthma burden. The present manuscript discusses the coding sequences or regulatory regions of genes that encode proteins involved in asthma pharmacological responses.

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Abbreviations

cAMP:

Cyclic adenosine monophosphate

FEV1:

Forced expiratory volume within 1 s

IL:

interleukin

LABA:

Long acting β2-agonist

SABA:

Short acting β2-agonist

SNP:

Single nucleotide polymorphism

UABA:

Ultra long acting beta2-agonist

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  1. Department of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

    Quan-Jun Yang & Cheng Guo

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  1. Quan-Jun Yang
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  1. Zhongshan Hospital Institute of Clinical Science, Shanghai Medical School Fudan University, Shanghai, China

    Xiangdong Wang

  2. Shanghai Respiratory Research Institute, Respiratory Division of Zhongshan Hospital, Fudan University, Shanghai, China

    Zhihong Chen

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Yang, QJ., Guo, C. (2018). Pharmacogenetic Study in Asthma. In: Wang, X., Chen, Z. (eds) Genomic Approach to Asthma. Translational Bioinformatics, vol 12. Springer, Singapore. https://doi.org/10.1007/978-981-10-8764-6_10

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