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The Use of Wolbachia by the World Mosquito Program to Interrupt Transmission of Aedes aegypti Transmitted Viruses

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Dengue and Zika: Control and Antiviral Treatment Strategies

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1062))

Abstract

The biological control of mosquito transmission by the use of the naturally occurring insect-specific bacterial endosymbiont Wolbachia has been successfully tested in small field trials. The approach has been translated successfully to larger field sites in Townsville, Australia and expanded to more than 10 countries through the Eliminate Dengue Program. The broader application of the program beyond limiting the transmission of dengue and including other Aedes aegypti borne mosquitoes has seen the program growing into a global not-for-profit initiative to be known as the World Mosquito Program.

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References

  1. Aliota MT, Peinado SA, Velez ID, Osorio JE (2016) The wMel strain of Wolbachia reduces transmission of Zika virus by Aedes aegypti. Sci Rep 6:28792

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Aliota MT, Walker EC, Uribe Yepes A, Dario Velez I, Christensen BM, Osorio JE (2016) The wMel strain of Wolbachia reduces transmission of chikungunya virus in Aedes aegypti. PLoS Negl Trop Dis e0004677:10

    Google Scholar 

  3. Dutra HL, Rocha MN, Dias FB, Mansur SB, Caragata EP, Moreira LA (2016) Wolbachia blocks currently circulating Zika virus isolates in Brazilian Aedes aegypti mosquitoes. Cell Host Microbe 19:771–774

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Ferguson NM, Kien DT, Clapham H, Aguas R, Trung VT, Chau TN, Popovici J, Ryan PA, O’Neill SL, McGraw EA, Long VT, Dui Le T, Nguyen HL, Chau NV, Wills B, Simmons CP (2015) Modeling the impact on virus transmission of Wolbachia-mediated blocking of dengue virus infection of Aedes aegypti. Sci Transl Med 7:279ra37

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Frentiu FD, Zakir T, Walker T, Popovici J, Pyke AT, Van Den Hurk A, McGraw EA, O’Neill SL (2014) Limited dengue virus replication in field-collected Aedes aegypti mosquitoes infected with Wolbachia. PLoS Negl Trop Dis 8:e2688

    Article  PubMed  PubMed Central  Google Scholar 

  6. Hilgenboecker K, Hammerstein P, Schlattmann P, Telschow A, Werren JH (2008) How many species are infected with Wolbachia? a statistical analysis of current data. FEMS Microbiol Lett 281:215–220

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Hoffmann AA, Montgomery BL, Popovici J, Iturbe-Ormaetxe I, Johnson PH, Muzzi F, Greenfield M, Durkan M, Leong YS, Dong Y, Cook H, Axford J, Callahan AG, Kenny N, Omodei C, Mcgraw EA, Ryan PA, Ritchie SA, Turelli M, O’Neill SL (2011) Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission. Nature 476:454–457

    Article  CAS  PubMed  Google Scholar 

  8. Hoffmann M, Coy MR, Kingdom Gibbard HN, Pelz-Stelinski KS (2014) Wolbachia infection density in populations of the Asian citrus psyllid (Hemiptera: Liviidae). Environ Entomol 43:1215–1222

    Article  CAS  PubMed  Google Scholar 

  9. Moreira LA, Iturbe-Ormaetxe I, Jeffery JA, Lu G, Pyke AT, Hedges LM, Rocha BC, Hall-Mendelin S, Day A, Riegler M, Hugo LE, Johnson KN, Kay BH, Mcgraw EA, Van Den Hurk AF, Ryan PA, O’Neill SL (2009) A Wolbachia symbiont in Aedes aegypti limits infection with dengue, chikungunya, and plasmodium. Cell 139:1268–1278

    Article  PubMed  Google Scholar 

  10. Murray JV, Jansen CC, Ede Barro P (2016) Risk associated with the release of Wolbachia-infected Aedes aegypti mosquitoes into the environment in an effort to control dengue. Front Public Health 4:43

    Article  PubMed  PubMed Central  Google Scholar 

  11. Walker T, Johnson PH, Moreira LA, Iturbe-Ormaetxe I, Frentiu FD, Mcmeniman CJ, Leong YS, Dong Y, Axford J, Kriesner P, Lloyd AL, Ritchie SA, O’Neill SL, Hoffmann AA (2011) The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations. Nature 476:450–453

    Article  CAS  PubMed  Google Scholar 

  12. Werren JH, Baldo L, Clark ME (2008) Wolbachia: master manipulators of invertebrate biology. Nat Rev Microbiol 6:741–751

    Article  CAS  Google Scholar 

  13. WHO (2016) Mosquito (vector) control emergency response and preparedness for Zika virus [Online]. Available: http://www.who.int/neglected_diseases/news/mosquito_vector_control_response/en/. Accessed 15 May 2016

  14. Zug R, Hammerstein P (2012) Still a host of hosts for Wolbachia: analysis of recent data suggests that 40% of terrestrial arthropod species are infected. PLoS One 7:e38544

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Scott L. O’Neill .

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O’Neill, S.L. (2018). The Use of Wolbachia by the World Mosquito Program to Interrupt Transmission of Aedes aegypti Transmitted Viruses. In: Hilgenfeld, R., Vasudevan, S. (eds) Dengue and Zika: Control and Antiviral Treatment Strategies. Advances in Experimental Medicine and Biology, vol 1062. Springer, Singapore. https://doi.org/10.1007/978-981-10-8727-1_24

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