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A New Strategy for Diagnosing of Squamous Intraepithelial Neoplasia of the Cervix

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Pathology of Female Cancers

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Abstract

In 2014 the World Health Organization classification of female genital tract tumors was revised and published to employ the histopathologic term squamous intraepithelial lesion (SIL), which the Bethesda system had introduced to standardize cytology reporting in 1988. This revision reflects a paradigm shift in the views regarding the morphological and biological aspects of precancerous squamous lesions of the uterine cervix. Low-grade SIL is defined as productive human papillomavirus (HPV) infection, whereas high-grade SIL represents a neoplastic condition resulting from transformation owing to the integration of HPV DNA into the host genome. Currently, a variety of ancillary methods, including immunohistochemistry (IHC), contribute to establishing a correct diagnosis or optimal management for women with SIL. For example, a combination of Ki-67 and p16INK4a IHC, as well as HPV IHC or in situ hybridization, is routinely used to facilitate diagnosis. In this chapter, current concepts, controversies, and diagnostic strategies for SIL are discussed.

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Authors and Affiliations

  1. Department of Diagnostic Pathology, Kumamoto Univerisity Hospital, Kumamoto, Kumamoto, Japan

    Yoshiki Mikami

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  1. Yoshiki Mikami
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Correspondence to Yoshiki Mikami .

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Editors and Affiliations

  1. Department of Pathology, Kawasaki Medical School, Kurashiki, Japan

    Takuya Moriya

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Mikami, Y. (2018). A New Strategy for Diagnosing of Squamous Intraepithelial Neoplasia of the Cervix. In: Moriya, T. (eds) Pathology of Female Cancers. Springer, Singapore. https://doi.org/10.1007/978-981-10-8606-9_1

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  • DOI: https://doi.org/10.1007/978-981-10-8606-9_1

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-8605-2

  • Online ISBN: 978-981-10-8606-9

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