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Mass Spectrometry-Based Techniques for the Assessment of Pharmacological Responses of Ayurvedic Drugs

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Anticancer plants: Properties and Application

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Abstract

Ayurvedic drugs are multicomponent mixtures from the same chemical or different classes of chemical compounds. A detailed evaluation on the pharmacological responses of these multicomponent drugs is the key area for understanding their pharmacological and toxicological profiles. In a critical evaluation of pharmacological responses, it is essential that pathophysiological reversal of pathways and biomarker response assessment be studied. High-quality studies are necessary to evaluate and compare the value of traditional Indian drugs to modern medicine. Mass spectrometry has evolved tremendously in the past few decades in terms of scope and applicability in various fields of science. In comparison with all other analytical techniques, MS provides a better sensitivity, resolution, a wider range of covered metabolites, higher reproducibility, and short analysis time for confident identification. Thus, the aim of this chapter is to closely look at the upgraded features of mass spectrometry techniques for the chemical characterization of multicomponent Ayurvedic drugs/formulations and for the assessment of complex pharmacological responses of these interventions in various biological systems.

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Acknowledgement

The authors are grateful to the Director General, CCRAS, New Delhi, for the moral supporting during this work.

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Authors and Affiliations

  1. Department of Pharmacology, National Research Institute of Basic Ayurvedic Sciences (NRIBAS), Pune, Maharashtra, India

    Amey Shirolkar, Manasi Malgaonkar, Amit Pawase & Sharad Pawar

  2. Central Council for Research in Ayurvedic Sciences (CCRAS), Janakpuri, New Delhi, India

    Sudesh Gaidhani

Authors
  1. Amey Shirolkar
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  2. Manasi Malgaonkar
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  3. Amit Pawase
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  4. Sudesh Gaidhani
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  5. Sharad Pawar
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Editors and Affiliations

  1. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

    Mohd Sayeed Akhtar

  2. Department of Crop Science Faculty of Agriculture, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Mallappa Kumara Swamy

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Shirolkar, A., Malgaonkar, M., Pawase, A., Gaidhani, S., Pawar, S. (2018). Mass Spectrometry-Based Techniques for the Assessment of Pharmacological Responses of Ayurvedic Drugs. In: Akhtar, M., Swamy, M. (eds) Anticancer plants: Properties and Application. Springer, Singapore. https://doi.org/10.1007/978-981-10-8548-2_8

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