Abstract
This chapter provides a brief overview of the systems, cellular, and molecular structure of the various nuclei of basal ganglia (BG) such as striatum, STN, GPe, GPi, and the SNr including the various neurotransmitters impacting its function. We start with the system-level connection between cortex and BG and then cover the various cell types, receptors (such as dopaminergic, acetylcholine) present on each of the BG nuclei. The effect of Parkinson’s disease on their dynamics especially the STN–GPe oscillatory network is then discussed. The dopaminergic systems SNc and VTA are also covered in terms of their architecture and input–output synaptic projection patterns. Finally, a short intro to the multiple cortico-BG loops and their functional relevance is discussed. This brief overview helps provide background on BG structure, which is the basis of several models we present in this book.
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References
Alberico, S. L., Cassell, M. D., & Narayanan, N. S. (2015). The vulnerable ventral tegmental area in Parkinson’s disease. Basal ganglia, 5(2), 51–55.
Albin, R. L., Young, A. B., & Penney, J. B. (1989). The functional anatomy of basal ganglia disorders. Trends in Neurosciences, 12(10), 366–375.
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience, 9(1), 357–381.
Aravamuthan, B., Muthusamy, K., Stein, J., Aziz, T., & Johansen-Berg, H. (2007). Topography of cortical and subcortical connections of the human pedunculopontine and subthalamic nuclei. Neuroimage, 37(3), 694–705.
Basso, M. A., Powers, A. S., & Evinger, C. (1996). An explanation for reflex blink hyperexcitability in Parkinson’s disease. I. Superior colliculus. The Journal of Neuroscience, 16(22), 7308–7317.
Baufreton, J., Kirkham, E., Atherton, J. F., Menard, A., Magill, P. J., Bolam, J. P., et al. (2009). Sparse but selective and potent synaptic transmission from the globus pallidus to the subthalamic nucleus. Journal of Neurophysiology, 102(1), 532–545.
Baunez, C., Humby, T., Eagle, D. M., Ryan, L. J., Dunnett, S. B., & Robbins, T. W. (2001). Effects of STN lesions on simple vs choice reaction time tasks in the rat: preserved motor readiness, but impaired response selection. European Journal of Neuroscience, 13(8), 1609–1616.
Beaulieu, J. M., & Gainetdinov, R. R. (2011). The physiology, signaling, and pharmacology of dopamine receptors. Pharmacological Reviews, 63(1), 182–217.
Benazzouz, A., Breit, S., Koudsie, A., Pollak, P., Krack, P., & Benabid, A. L. (2002). Intraoperative microrecordings of the subthalamic nucleus in Parkinson’s disease. Movement Disorders, 17(S3), S145–S149.
Bennett, B. D., Callaway, J. C., & Wilson, C. J. (2000). Intrinsic membrane properties underlying spontaneous tonic firing in neostriatal cholinergic interneurons. The Journal of Neuroscience, 20(22), 8493–8503.
Bergman, H., Feingold, A., Nini, A., Raz, A., Slovin, H., Abeles, M., & Vaadia, E. (1998). Physiological aspects of information processing in the basal ganglia of normal and Parkinsonian primates. Trends in Neurosciences, 21(1), 32–38.
Bergman, H., Wichmann, T., Karmon, B., & DeLong, M. (1994). The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of Parkinsonism. Journal of Neurophysiology, 72(2), 507–520.
Beurrier, C., Congar, P., Bioulac, B., & Hammond, C. (1999). Subthalamic nucleus neurons switch from single-spike activity to burst-firing mode. The Journal of Neuroscience, 19(2), 599–609.
Bevan, M. D., Magill, P. J., Terman, D., Bolam, J. P., & Wilson, C. J. (2002). Move to the rhythm: Oscillations in the subthalamic nucleus–external globus pallidus network. Trends in Neurosciences, 25(10), 525–531.
Bevan, M. D., & Wilson, C. J. (1999). Mechanisms underlying spontaneous oscillation and rhythmic firing in rat subthalamic neurons. The Journal of Neuroscience, 19(17), 7617–7628.
Björklund, A., & Dunnett, S. B. (2007). Dopamine neuron systems in the brain: An update. Trends in Neurosciences, 30(5), 194–202.
Blandini, F. (2010). An update on the potential role of excitotoxicity in the pathogenesis of Parkinson’s disease. Functional Neurology, 25(2), 65.
Bolam, J., Bergman, H., Graybiel, A., Kimura, M., Plenz, D., Seung, H., … Wickens, J. (2006). Microcircuits, molecules and motivated behaviour: Microcircuits in the striatum. Paper presented at the Microcircuits: The Interface Between Neurons and Global Brain Function, Dahlem Workshop Report.
Brown, P. (2003). Oscillatory nature of human basal ganglia activity: relationship to the pathophysiology of Parkinson’s disease. Movement Disorders, 18(4), 357–363.
Brown, P. (2007). Abnormal oscillatory synchronisation in the motor system leads to impaired movement. Current Opinion in Neurobiology, 17(6), 656–664.
Brown, P., Oliviero, A., Mazzone, P., Insola, A., Tonali, P., & Di Lazzaro, V. (2001). Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson’s disease. The Journal of Neuroscience, 21(3), 1033–1038.
Chakravarthy, V., Joseph, D., & Bapi, R. S. (2010). What do the basal ganglia do? A modeling perspective. Biological Cybernetics, 103(3), 237–253.
Charpier, S., Beurrier, C., & Paz, J. (2010). The subthalamic nucleus: from in vitro to in vivo mechanisms. Handbook of Basal Ganglia Structure and Function, 259–273.
Chaudhuri, K. R., Healy, D. G., & Schapira, A. H. (2006). Non-motor symptoms of Parkinson’s disease: diagnosis and management. The Lancet Neurology, 5(3), 235–245.
Chaudhuri, K. R., Odin, P., Antonini, A., & Martinez-Martin, P. (2011). Parkinson’s disease: The non-motor issues. Parkinsonism & Related Disorders, 17(10), 717–723.
Chersi, F., Mirolli, M., Pezzulo, G., & Baldassarre, G. (2013). A spiking neuron model of the cortico-basal ganglia circuits for goal-directed and habitual action learning. Neural Networks, 41, 212–224.
DeLong, M., & Wichmann, T. (2010). Changing views of basal ganglia circuits and circuit disorders. Clinical EEG and Neuroscience, 41(2), 61–67.
Deniau, J., Hammond, C., Riszk, A., & Feger, J. (1978). Electrophysiological properties of identified output neurons of the rat substantia nigra (pars compacta and pars reticulata): Evidences for the existence of branched neurons. Experimental Brain Research, 32(3), 409–422.
Fan, K. Y., Baufreton, J., Surmeier, D. J., Chan, C. S., & Bevan, M. D. (2012). Proliferation of external globus pallidus-subthalamic nucleus synapses following degeneration of midbrain dopamine neurons. The Journal of Neuroscience, 32(40), 13718–13728.
Foffani, G., Bianchi, A., Baselli, G., & Priori, A. (2005). Movement-related frequency modulation of beta oscillatory activity in the human subthalamic nucleus. The Journal of Physiology, 568(2), 699–711.
Gerfen, C. R. (1984). The neostriatal mosaic: compartmentalization of corticostriatal input and striatonigral output systems. Nature, 311(5985), 461.
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F., & Sibley, D. R. (1990). D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science, 250(4986), 1429–1432.
Gerfen, C. R., & Surmeier, D. J. (2011). Modulation of striatal projection systems by dopamine. Annual Review of Neuroscience, 34, 441.
Gerfen, C. R., & Young, W. S. (1988). Distribution of striatonigral and striatopallidal peptidergic neurons in both patch and matrix compartments: An in situ hybridization histochemistry and fluorescent retrograde tracing study. Brain Research, 460(1), 161–167.
Gillies, A., Willshaw, D., Gillies, A., & Willshaw, D. (1998). A massively connected subthalamic nucleus leads to the generation of widespread pulses. Proceedings of the Royal Society of London, Series B: Biological Sciences, 265(1410), 2101–2109.
Grace, A., & Bunney, B. (1983). Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—2. Action potential generating mechanisms and morphological correlates. Neuroscience, 10(2), 317–331.
Graybiel, A. M., Aosaki, T., Flaherty, A. W., & Kimura, M. (1994). The basal ganglia and adaptive motor control. Science, 265(5180), 1826–1831.
Gurney, K., Prescott, T. J., & Redgrave, P. (2001a). A computational model of action selection in the basal ganglia. I. A new functional anatomy. Biological Cybernetics, 84(6), 401–410.
Gurney, K., Prescott, T. J., & Redgrave, P. (2001b). A computational model of action selection in the basal ganglia. II. Analysis and simulation of behaviour. Biological Cybernetics, 84(6), 411–423.
Haber, S. N., & Calzavara, R. (2009). The cortico-basal ganglia integrative network: The role of the thalamus. Brain Research Bulletin, 78(2), 69–74.
Haber, S. N., Fudge, J. L., & McFarland, N. R. (2000). Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. The Journal of Neuroscience, 20(6), 2369–2382.
Hammond, C., Bergman, H., & Brown, P. (2007). Pathological synchronization in Parkinson’s disease: Networks, models and treatments. Trends in Neurosciences, 30(7), 357–364.
Han, X., Jing, M.-y., Zhao, T.-y., Wu, N., Song, R., & Li, J. (2017). Role of dopamine projections from ventral tegmental area to nucleus accumbens and medial prefrontal cortex in reinforcement behaviors assessed using optogenetic manipulation. Metabolic Brain Disease, 1–12.
Hasbi, A., O’Dowd, B. F., & George, S. R. (2011). Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance. Molecular Brain, 4(1), 26.
Heida, T., Lakke, E. A., & Usunoff, K. G. (2008a). Subthalamic nucleus Part I: Development, cytology, topography and connections, the advances in anatomy, embryology and cell biology. Berlin: Springer.
Heida, T., Marani, E., & Usunoff, K. G. (2008b). The subthalamic nucleus: Part II: Modelling and simulation of activity. Berlin: Springer.
Holgado, A. J. N., Terry, J. R., & Bogacz, R. (2010). Conditions for the generation of beta oscillations in the subthalamic nucleus–globus pallidus network. The Journal of Neuroscience, 30(37), 12340–12352.
Humphries, M., & Gurney, K. (2002). The role of intra-thalamic and thalamocortical circuits in action selection. Network: Computation in Neural Systems, 13(1), 131–156.
Kawaguchi, Y. (1993). Physiological, morphological, and histochemical characterization of three classes of interneurons in rat neostriatum. The Journal of Neuroscience, 13(11), 4908–4923.
Kita, H., Chang, H., & Kitai, S. (1983). The morphology of intracellularly labeled rat subthalamic neurons: A light microscopic analysis. Journal of Comparative Neurology, 215(3), 245–257.
Kita, H., & Kita, S. (1994). The morphology of globus pallidus projection neurons in the rat: An intracellular staining study. Brain Research, 636(2), 308–319.
Knable, M. B., & Weinberger, D. R. (1997). Dopamine, the prefrontal cortex and schizophrenia. Journal of psychopharmacology, 11(2), 123–131.
Koós, T., & Tepper, J. M. (1999). Inhibitory control of neostriatal projection neurons by GABAergic interneurons. Nature Neuroscience, 2(5), 467–472.
Kreitzer, A. C. (2009). Physiology and pharmacology of striatal neurons. Annual Review of Neuroscience, 32, 127–147.
Lawson, R., Seymour, B., Nord, C., Thomas, D., Roiser, J., Dayan, P., & Pilling, S. (2016). Disrupted habenula function in major depression. Molecular psychiatry, 22(2), 202.
Lee, C. R., & Tepper, J. M. (2009). Basal ganglia control of substantia nigra dopaminergic neurons. In Birth, life and death of dopaminergic neurons in the substantia nigra (pp. 71–90), Berlin: Springer.
Levy, R., Ashby, P., Hutchison, W. D., Lang, A. E., Lozano, A. M., & Dostrovsky, J. O. (2002). Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson’s disease. Brain, 125(6), 1196–1209.
Mallet, N., Le Moine, C., Charpier, S., & Gonon, F. (2005). Feedforward inhibition of projection neurons by fast-spiking GABA interneurons in the rat striatum in vivo. The Journal of Neuroscience, 25(15), 3857–3869.
Marsden, C. (1986). Movement disorders and the basal ganglia. Trends in neurosciences, 9, 512–515.
Maurice, N., Deniau, J.-M., Glowinski, J., & Thierry, A.-M. (1998). Relationships between the prefrontal cortex and the basal ganglia in the rat: physiology of the corticosubthalamic circuits. The Journal of Neuroscience, 18(22), 9539–9546.
Merello, M. (2007). Non-motor disorders in Parkinson’s disease. Revista de neurologia, 47(5), 261–270.
Middleton, F. A., & Strick, P. L. (1996). The temporal lobe is a target of output from the basal ganglia. Proceedings of the national academy of sciences, 93(16), 8683–8687.
Morales, M., & Margolis, E. B. (2017). Ventral tegmental area: cellular heterogeneity, connectivity and behaviour. Nature Reviews Neuroscience, 18(2), 73–85.
Nakanishi, H., Kita, H., & Kitai, S. (1987). Intracellular study of rat substantia nigra pars reticulata neurons in an in vitro slice preparation: Electrical membrane properties and response characteristics to subthalamic stimulation. Brain Research, 437(1), 45–55.
Nakano, K. (2000). Neural circuits and topographic organization of the basal ganglia and related regions. Brain and Development, 22, 5–16.
Nambu, A., Tokuno, H., & Takada, M. (2002). Functional significance of the cortico–subthalamo–pallidal ‘hyperdirect’ pathway. Neuroscience Research, 43(2), 111–117.
Nicola, S. M., Surmeier, D. J., & Malenka, R. C. (2000). Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens. Annual Review of Neuroscience, 23(1), 185–215.
Oliva, I., & Wanat, M. J. (2016). Ventral tegmental area afferents and drug-dependent behaviors. Frontiers in psychiatry, 7.
Park, C., Worth, R. M., & Rubchinsky, L. L. (2010). Fine temporal structure of beta oscillations synchronization in subthalamic nucleus in Parkinson’s disease. Journal of Neurophysiology, 103(5), 2707–2716.
Park, C., Worth, R. M., & Rubchinsky, L. L. (2011). Neural dynamics in Parkinsonian brain: The boundary between synchronized and nonsynchronized dynamics. Physical Review E, 83(4), 042901.
Plenz, D., & Kitai, S. T. (1998). Up and down states in striatal medium spiny neurons simultaneously recorded with spontaneous activity in fast-spiking interneurons studied in cortex–striatum–substantia nigra organotypic cultures. The Journal of Neuroscience, 18(1), 266–283.
Plenz, D., & Kital, S. T. (1999). A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus. Nature, 400(6745), 677–682.
Rashid, A. J., So, C. H., Kong, M. M., Furtak, T., El-Ghundi, M., Cheng, R., … George, S. R. (2007). D1–D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. Proceedings of the National Academy of Sciences, 104(2), 654–659.
Raz, A., Vaadia, E., & Bergman, H. (2000). Firing patterns and correlations of spontaneous discharge of pallidal neurons in the normal and the tremulous 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine vervet model of Parkinsonism. The Journal of Neuroscience, 20(22), 8559–8571.
Reig, R., & Silberberg, G. (2014). Multisensory integration in the mouse striatum. Neuron, 83(5), 1200–1212.
Robledo, P., & Féger, J. (1990). Excitatory influence of rat subthalamic nucleus to substantia nigra pars reticulata and the pallidal complex: Electrophysiological data. Brain Research, 518(1), 47–54.
Rodriguez-Oroz, M. C., López-Azcárate, J., Garcia-Garcia, D., Alegre, M., Toledo, J., Valencia, M., … Obeso, J. A. (2010). Involvement of the subthalamic nucleus in impulse control disorders associated with Parkinson’s disease. Brain, awq301.
Rubin, J. E., & Terman, D. (2004). High frequency stimulation of the subthalamic nucleus eliminates pathological thalamic rhythmicity in a computational model. Journal of Computational Neuroscience, 16(3), 211–235.
Sato, F., Lavallée, P., Lévesque, M., & Parent, A. (2000). Single-axon tracing study of neurons of the external segment of the globus pallidus in primate. Journal of Comparative Neurology, 417(1), 17–31.
Schrag, A., & Quinn, N. (2000). Dyskinesias and motor fluctuations in Parkinson’s disease. Brain, 123(11), 2297–2305.
Schroll, H., Vitay, J., & Hamker, F. H. (2012). Working memory and response selection: A computational account of interactions among cortico-basalganglio-thalamic loops. Neural Networks, 26, 59–74.
Schultz, W. (1998). Predictive reward signal of dopamine neurons. Journal of neurophysiology, 80(1), 1–27.
Seeman, P. (1980). Brain dopamine receptors. Pharmacological Reviews, 32(3), 229–313.
Singleton, A., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., … Nussbaum, R. (2003). α-Synuclein locus triplication causes Parkinson’s disease. Science, 302(5646), 841–841.
Stamatakis, A. M., Jennings, J. H., Ung, R. L., Blair, G. A., Weinberg, R. J., Neve, R. L., … Deisseroth, K. (2013). A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward. Neuron, 80(4), 1039–1053.
Steiner, H., & Tseng, K. Y. (2010). Handbook of Basal Ganglia Structure and Function: A Decade of Progress (Vol. 20), Access Online via Elsevier.
Surmeier, D. J., Ding, J., Day, M., Wang, Z., & Shen, W. (2007). D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons. Trends in Neurosciences, 30(5), 228–235.
Surmeier, D. J., Song, W.-J., & Yan, Z. (1996). Coordinated expression of dopamine receptors in neostriatal medium spiny neurons. The Journal of Neuroscience, 16(20), 6579–6591.
Swanson, L. (1982). The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. Brain research bulletin, 9(1), 321–353.
Tachibana, Y., Iwamuro, H., Kita, H., Takada, M., & Nambu, A. (2011). Subthalamo-pallidal interactions underlying Parkinsonian neuronal oscillations in the primate basal ganglia. European Journal of Neuroscience, 34(9), 1470–1484.
Tepper, J., Martin, L., & Anderson, D. (1995). GABA~A Receptor-Mediated Inhibition of Rat Substantia Nigra Dopaminergic Neurons by Pars Reticulata Projection Neurons. Journal of Neuroscience, 15(4), 3092–3103.
Weinberger, M., & Dostrovsky, J. O. (2011). A basis for the pathological oscillations in basal ganglia: the crucial role of dopamine. NeuroReport, 22(4), 151.
Willshaw, D., & Li, Z. (2002). Subthalamic–pallidal interactions are critical in determining normal and abnormal functioning of the basal ganglia. Proceedings of the Royal Society of London, Series B: Biological Sciences, 269(1491), 545–551.
Wilson, C. J., & Bevan, M. D. (2011). Intrinsic dynamics and synaptic inputs control the activity patterns of subthalamic nucleus neurons in health and in Parkinson’s disease. Neuroscience, 198, 54–68.
Wood-Kaczmar, A., Gandhi, S., & Wood, N. (2006). Understanding the molecular causes of Parkinson’s disease. Trends in Molecular Medicine, 12(11), 521–528.
Xia, R., & Mao, Z.-H. (2012). Progression of motor symptoms in Parkinson’s disease. Neuroscience Bulletin, 28(1), 39–48.
Yelnik, J. (2002). Functional anatomy of the basal ganglia. Movement Disorders, 17(S3), S15–S21.
Yamaguchi, T., Wang, H.-L., Li, X., Ng, T. H., & Morales, M. (2011). Mesocorticolimbic glutamatergic pathway. Journal of Neuroscience, 31(23), 8476–8490.
Yucelgen, C., Denizdurduran, B., Metin, S., Elibol, R., & Sengor, N. S. (2012). A biophysical network model displaying the role of basal ganglia pathways in action selection. In Artificial neural networks and machine learning–ICANN 2012 (pp. 177–184), Berlin: Springer.
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Mandali, A., Srinivasa Chakravarthy, V., Moustafa, A.A. (2018). The Molecular, Cellular, and Systems-Level Structure of the Basal Ganglia. In: Computational Neuroscience Models of the Basal Ganglia. Cognitive Science and Technology. Springer, Singapore. https://doi.org/10.1007/978-981-10-8494-2_2
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