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Oligomerization of Retrovirus Integrases

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Virus Protein and Nucleoprotein Complexes

Part of the book series: Subcellular Biochemistry ((SCBI,volume 88))

Abstract

Integration of the reverse-transcribed viral cDNA into the host’s genome is a critical step in the lifecycle of all retroviruses. Retrovirus integration is carried out by integrase (IN), a virus-encoded enzyme that forms an oligomeric ‘intasome’ complex with both ends of the linear viral DNA to catalyze their concerted insertions into the backbones of the host’s DNA. IN also forms a complex with host proteins, which guides the intasome to the host’s chromosome. Recent structural studies have revealed remarkable diversity as well as conserved features among the architectures of the intasome assembly from different genera of retroviruses. This chapter will review how IN oligomerizes to achieve its function, with particular focus on alpharetrovirus including the avian retrovirus Rous sarcoma virus. Another chapter (Craigie) will focus on the structure and function of IN from HIV-1.

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Authors and Affiliations

  1. Saint Louis University Health Sciences Center, Department of Microbiology and Immunology, Institute for Molecular Virology, Doisy Research Center, St. Louis, MO, USA

    Duane P. Grandgenett

  2. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA

    Hideki Aihara

Authors
  1. Duane P. Grandgenett
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  2. Hideki Aihara
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Correspondence to Hideki Aihara .

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Editors and Affiliations

  1. Institute of Zoology, University of Mainz, Mainz, Germany

    J. Robin Harris

  2. MRC-University of Glasgow Centre for Virus Research, Glasgow, UK

    David Bhella

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Grandgenett, D.P., Aihara, H. (2018). Oligomerization of Retrovirus Integrases. In: Harris, J., Bhella, D. (eds) Virus Protein and Nucleoprotein Complexes. Subcellular Biochemistry, vol 88. Springer, Singapore. https://doi.org/10.1007/978-981-10-8456-0_10

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