Abstract
The survival rates of cancer patients are decreasing over the years which are possibly due to selection of poor conventional anti-cancer drugs. At present complementary and alternate medicines (CAM) are high on demand as they show few or rather zero side-effects. Metabolomic analysis is considered to be a complex as well as efficient bridge between CAM and plants and its therapeutic possibilities as optimized and subscribed medicines. Metabolomics, considered to be the smallest domain comprises approximately 5000 metabolites, is chemically and physically more complex as compared to genomics (30,000 genes) and proteomics (100,000 or more proteins) associated with anti-cancer properties as it involves diverse groups of biological molecules. Stress on the cellular activity is inflicted directly by changes in the metabolome of an organism which underlines the importance of metabolomics in disease diagnosis and drug discovery. The present chapter focuses on the recent progresses in metabolomics which have transformed it to become a robust systems biology tool in studying both chemical and biochemical events that contribute to the cancer prevention activities of plant preparations or their bioactive components. Variations in the metabolome of cancer cell lines on treatment with plant extracts are also discussed. The current status of metabolic engineering efforts is highlighted for in vitro production of different chemo-preventive compounds viz. paclitaxel, geraniol, methyl cinnamate, Δ9-tetrahydrocannabinol, etc. in their respective medicinal plants. The aim of present chapter is to explore the feasibility of metabolomic analysis of potent anticancer plants in order to search for the lead chemo-preventive compounds and also, to integrate the traditional cancer therapy with metabolomic profiling for the cure of cancer.
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Parasar, N.R., Chikkaputtaiah, C., Lal, M., Akhtar, M.S. (2018). Metabolomic Study of Chemo-preventive Phytochemicals and Their Therapeutic Prospects. In: Akhtar, M., Swamy, M. (eds) Anticancer Plants: Mechanisms and Molecular Interactions. Springer, Singapore. https://doi.org/10.1007/978-981-10-8417-1_8
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