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Anticancer Plants: Mechanisms and Molecular Interactions pp 143–163Cite as

Anticancer Potential of Andrographolide, a Diterpenoid Lactone from Andrographis paniculata: A Nature’s Treasure for Chemoprevention and Therapeutics

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Abstract

Cancer is one of the major causes of mortality in human population worldwide. The conventional drugs are known to be accompanied with severe side effects. Thus, the recent research is focused to find out the new chemotherapeutic agents of natural origin (plants derived) against cancer, which have the least side effects. In this regard, andrographolide, a major bioactive compound of a traditional medicinal plant, Andrographis paniculata has drawn much attention. It has shown a strong anticancer potential in several in vitro and in vivo studies against different cancers because of its ability to inhibit cell cycle progression in cancer cells. Moreover, it has also shown antimetastatic and antiangiogenic properties in different cancer cells through various underlying molecular mechanism of action. Recently, the roles of andrographolide in cancer progression via cellular developmental pathways have gained attention. Thus, the aim of this chapter is to summarize the anticancer potential of andrographolide and provide an insight in identifying new molecular targets for developing new cancer treatment strategies.

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Authors and Affiliations

  1. Department of Biosciences, Integral University, Lucknow, Uttar Pradesh, India

    Imran Khan & Irfan Ahmad Ansari

  2. Department of Bioengineering, Integral University, Lucknow, Uttar Pradesh, India

    Mohd Aslam Yusuf

  3. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

    Mohd Sayeed Akhtar

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  1. Imran Khan
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  2. Mohd Aslam Yusuf
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  3. Irfan Ahmad Ansari
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  4. Mohd Sayeed Akhtar
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Correspondence to Irfan Ahmad Ansari or Mohd Sayeed Akhtar .

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Editors and Affiliations

  1. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

    Mohd Sayeed Akhtar

  2. Department of Crop Science,Faculty of Agriculture, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Mallappa Kumara Swamy

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Khan, I., Yusuf, M.A., Ansari, I.A., Akhtar, M.S. (2018). Anticancer Potential of Andrographolide, a Diterpenoid Lactone from Andrographis paniculata: A Nature’s Treasure for Chemoprevention and Therapeutics. In: Akhtar, M., Swamy, M. (eds) Anticancer Plants: Mechanisms and Molecular Interactions. Springer, Singapore. https://doi.org/10.1007/978-981-10-8417-1_6

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