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Phytoestrogens as a Natural Source for the Possible Colon Cancer Treatment

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Anticancer Plants: Mechanisms and Molecular Interactions

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Abstract

Phytoestrogens (PEs) are naturally available bioactive compounds widely available in a spectrum of sources such as plant foods and are said to exhibit estrogen-like, antioxidant, and anticancer properties. There are wide range of PE-containing sources which are usually consumed by humans such as isoflavones (IF), coumestans, and lignans. Many of the fruits, vegetables, and whole grains are known to contain PE. For example, soybeans mainly contain IF, and flaxseeds mostly contain lignans, while clover, alfalfa, and soybean sprouts are rich in coumestans. There are many factors which affect the way these compounds act in a cell type such as estrogen receptor (ER)-α and ER-β levels and the amount of co-activators and corepressors present. The proposed mechanism by which these PEs work is by exerting their antioxidant effects through the inhibition of tyrosine kinase as well as DNA topoisomerase activities and also by suppressing the process of angiogenesis. Findings from molecular, cellular, and animal studies suggest that PE may potentially confer health benefits related to colon cancer (CC) pathology. High incidence of CC might be resulted with the intake of high-calorie diet including consumption of saturated fat and practicing sedentary lifestyle, whereas PEs from fiber-rich food could serve as prophylactics. The aim of this chapter is to elucidate the mechanistic approaches of different plant-based estrogens in combating colon cancer and their possible beneficial and clinical effects and therapeutic implications.

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  1. Department of Biochemistry, National Institute of Nutrition, Hyderabad, Telangana, India

    Suresh Challa, Rajanna Ajumeera & Naresh Venna

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  1. Suresh Challa
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  2. Rajanna Ajumeera
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  3. Naresh Venna
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Correspondence to Suresh Challa .

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Editors and Affiliations

  1. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

    Mohd Sayeed Akhtar

  2. Department of Crop Science,Faculty of Agriculture, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Mallappa Kumara Swamy

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Challa, S., Ajumeera, R., Venna, N. (2018). Phytoestrogens as a Natural Source for the Possible Colon Cancer Treatment. In: Akhtar, M., Swamy, M. (eds) Anticancer Plants: Mechanisms and Molecular Interactions. Springer, Singapore. https://doi.org/10.1007/978-981-10-8417-1_11

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