Abstract
Ophiocordyceps sinensis, previously known as Cordyceps sinensis, popularly called as caterpillar mushroom is a non-toxic, medicinal fungus found growing in the Himalayan hills in India, Nepal, China and Tibet. In higher hills of Uttarakhand (India), this fungus is locally known as yarsha gamboo or kira ghas, since it parasitizes on the lepidopteran insect larvae of the caterpillar Thitarodes (Hepialus) armoricanus Oberthur of family Hepialidae under the soil (Huang 1999). The grasslands are habitat for Thitarodes armoricanus and hence for Ophiocordyceps sinensis because the former is the host insect for the latter in alpine meadows just above the tree line. Its local name in Uttarakhand is yarsha gamboo which is derived from yartsa gunbu, a Tibetan name meaning summer grass winter worm.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Anonymous (2015) Annual report, Defence Institute of Bioenergy Research(DRDO), Haldwani, Uttarakhand
Arif M, Kumar N (2003) Medicinal insects and insect – fungus relationship in high altitude areas of Kumaon Hills in Central Himalayas. J Expt Zoo India 6(1):45–55
Arora D (1986) Mushrooms demystified. Ten Speed Press, Berkeley, pp 1–959
Bao TT, Wang GF, Yang JL (1988) Pharmacological actions of Cordyceps. Chung His I Chieh Ho Tsa Chih 8(6):352–354
Blackwell M, Gilbertson RL (1984) New information on Cordycepioideus bisporus and Cordycepioideus octosporus. Mycologia 76:763–765
Boesi A (2003) The dbyarrtswadgun ‘bu (Cordyceps sinensis Berk): an important trade item for the Tibetan population of the Lithang County, Sichuan Province, China. Tibet J 28(3):29–42
Bok JW, Lermer L, Chilton J, Klingeman HG, Towerrs GH (1999) Antitumor sterols from the mycelia of Cordyceps sinensis. Phytochemistry 51(7):891–898
Chiou WF, Chang PC, Chou CJ, Chen CF (2000) Protein constituent contributes to the hypotensive and vasorelaxant activities of Cordyceps sinensis. Life Sci 66(14):1369–1376
Christensen CM (1975) Fungus predators and parasites. In: Christensen CM (ed) Moulds, mushrooms and mycotoxins. University of Minnesota Press, Minneapolis, p 164
Das SC, Negi PS, Arif M (2005) YarshaGamboo – the wonder drug of Himalayas. J Appl Zool Res 16(2):250–254
Dubey HC (1983) An introduction to fungi. Vikas Publishing House, New Delhi, pp 231–232
Evans HC, Samson RA (1982) Entomogenous fungi from the Galapagos Islands. Can J Bot 60:2325–2333
Gao HC, Gao JQ, Xi QY, Li XH (2003) Research and development for Cordyceps sinensis. J Microbiol 23:50–55
Garbyal SS (2001) Occurrence of Cordyceps sinensis in upper Himalaya, Dharchula Sub-Division, Pithoragarh District, Uttaranchal, India. Indian Forester 127(11):1229–1231
Garbyal SS, Aggarwal KK, Babu CR (2004) Impact of Cordyceps sinensis in the rural economy of interior villages of Dharchula sub-division of Kumaun Himalayas and its implication in the society. Indian J Tradt Knowl 3(2):182–186
Guo QC, Zhang C (1995) Clinical observations of adjunctive treatment of 20 diabetic patients with JinShuiBao capsule. J Admin Tradit Chin Med 5:22
Halpern GM (1999) Cordyceps, China’s healing mushroom. Avery Publishing Group, New York
Hobbs C (1995) Medicinal mushrooms: an exploration of tradition, healing and culture. Botanica Press, Santa Cruz, pp 81–86
Holliday J, Cleaver P, Loomis-Powers M, Patel D (2004) Analysis of quality and techniques for hybridization of medicinal fungus Cordyceps sinensis. Int J Med Mushrooms 6:147–160
Hodge KT (2003) Clavicipitacaeous anamorphs. In: White JF Jr, Bacon CW, Hywel-Jones NL, Spatafora JW (eds) Clavicipitalean fungi: evolutionary biology, chemistry, biocontrol and cultural impacts. Marcel Dekker Inc, New York, pp 75–123
Huang KC (1999) Tonics and supporting herbs. In: Huang KC (ed) The pharmacology of Chinese Herbs. CRC Press, Boca Raton, pp 263–264
Huang B, Li C, Humber RA, Hodge KT, Fan M, Li Z (2005) Molecular evidence for the taxonomic status of Metarhiziumtaii and its teleomorph, Cordycepstaii (Hypocreales, Clavicipitaceae). Mycotaxon 94:137–147
Huelsenbeck JP, Ronquist F (2001) MrBAYES: Bayesian inference of phylogenetic trees. Bioinformatics 17:754–755
Ito Y, Hirano T (1997) The determination of the partial 18S ribosomal DNA sequences of Cordyceps species. Lett Appl Microbiol 25:239–242
Kendrick B (1992) The fifth kingdom. Focus Publishing, Newburyport, pp 1–406
Kumar N, Negi PS (2003) Micropropagation of Cordyceps sinensis (Berk) Sacc., a high value medicinal fungus wildly growing in Himalayan region. Paper presented during Congress on in vitro Biology held at Portland, Oregon, May 31 – June 4 2003. In vitro Cell Dev Biol 39:1023 (abstract)
Kuo YC, Tsai WJ, Shiao MS, Chen CF, Lin C (1996) Cordyceps sinensis as an immunomodulatory agent. Am J Chin Med 24(2):111–125
Li BS (1993) The alpine timberline of Tibet. In: Alden J, Mastrantonio JL, Odum S (eds) Forest development in cold climates. Plenum Press, New York, pp 511–527
Li QS, Zeng W, Yin DH, Huang TF (1999) A preliminary study on alternation of generations of Cordyceps sinensis. Zhongguo Zhong Yao Za Zhi 23(4):210–212
Li ZZ, Li CR, Huang B, Fan MZ (2001) Discovery and demonstration of the teleomorph of Beauveria bassiana (Bals.) Vuill., an important entomopathogenic fungus. Chin Sci Bull 9:751–753
Liang ZQ (1991) Determination and identification of anamorph of Cordyceps pruinosa. Acta Mycol Sin 10:72–80
Liang ZQ, Liu AY, Liu JL (1991) A new species of the genus Cordyceps and its Metarhizium anamorph. Acta Mycol Sin 10:257–262
Liu ZY, Liang ZQ, Whalley AJS, Yao YJ, Liu AY (2001) Cordyceps brittlebankisoides, a new pathogen of grubs and its anamorph, Metarhizium anisopliae var. majus. J Invertebr Pathol 78:178–182
Manabe N, Sugimoto M, Azuma Y, Taketomo N, Yamashita A, Tsuboi H, Tsunoo A, Kinjo N, Nian-Lai H, Miyamoto H (1996) Effects of the mycelial extract of cultured Cordyceps sinensis on in vivo hepatic energy metabolism in the mouse. Jpn J Pharmacol 70(1):85–88
Massee G (1895) A revision of the genus Cordyceps. Ann Bot 9:1–44
Negi PS (2006) Systematics of mushrooms of Almora and Pithoragarh Districts. PhD thesis. University of Kumaon
Negi PS, Singh R, Ahmed Z (2010) Transfer of in vitro technology of Cordyceps to industry: a new hope for Indian Pharmaceuticals. SciRep:17
Nielsen ES, Robinson GS, Wagner DL (2000) Ghost-moths of the world: a global inventory and bibliography of the Exoporia (Mnesarchaeoidea and Hepialoidea) (Lepidoptera). J Nat Hist 34:823–878
Petch T (1924) Studies in entomogenous fungus. IV. Some Ceylon Cordyceps. Trans Br Mycol Soc 10:28–45
Sharma S (2004) Trade of Cordyceps sinensis from high altitude of the Indian Himalayas: conservation and biotechnological priorities. Curr Sci 86:1614–1619
Singh R, Negi PS, Ahmed Z (2010) Ophiocordyceps sinensis-valuable caterpillar fungus from the Himalayan hills. Curr Sci 99(7)
Spatafora JW, Sung G-H, Sung J-M, Hywel-Jones NL, White JF Jr (2007) Phylogenetic evidence for an animal pathogen origin for ergot and the grass endophytes. Mol Ecol 16:1701–1711
Sung JM (1996) The insects-born fungus of Korea in color. Kyohak Publishing, Seoul
Sung JM (2004) Cordyceps diversity and its preservation in Korea. Inoculum Suppl Mycol 55(4):1–3
Sung G-H, Spatafora JW, Zare R, Hodge KT, Gams W (2001) A revision of Verticillium sect. Prostrata. II. Phylogenetic analyses of SSU and LSU nuclear rDNA sequences from anamorphs and teleomorphs of the Clavicipitaceae. Nova Hedwig 72:311–328
Sung GH, Nigel L Hywel Jones, Sung JM, Jennifer JL, Bhushan S, Spatafora JW (2007a) Phylogenetic classification of Cordyceps and the clavicipitaceous fungi. Studies in Mycology 57: 5–59.
Sung GH, Sung JM, HywelJones NL, Spatafora JW (2007b) A multi-gene phylogeny of Clavicipitaceae (Ascomycota, fungi): identification of localized incongruence using a combinational bootstrap approach. Mol Phylogenet Evol 44:1204–1223.
UNW (1996) University of Nanjing webpages – catalog of outstanding examples in bioresources of food therapy. http://www.nju.edu.cn/foode/jun/b3.htm
Wang H (1999) Discussion of several issues regarding research and development of Cordyceps sinensis. In: Development of agriculture and pastoral production, vol 6, Nanchang, pp 21–22
Wang Sheng Y, Shiao-Ming S, Wang SY (2000) Pharmacological functions of Chinese medicinal fungus Cordyceps sinensis and related species. J Food Drug Anal 8(4):248–257
Wang SM, Lee LJ, Lin WW, Chung CM (1998a) J Cell Biochem 15 69(4):483–489
Wang W, Chen T, Li Q, Zhou S, Zhong Y (1998b) Studies on Cordyceps sinensis. II. Reviews concerning agamotype. Acta Edulis Fungi 5(4):17–22
Wasser SP (2002) Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol 60:258–274
Winkler D (2003) Forest use and implications of the 1998 logging ban in the Tibetan prefectures of Sichuan: case study on forestry, reforestation and NTFP in LitangCounty, Ganzi TAP, China. The ecological basis and sustainable management of forest resources. Informatore Botanico Italiano 35(Supp 1):116–125
Xie Z, Huang X, Lou Z, Li S, Zhou L, Yang Z, Tang Z (1988) Dictionary of traditional Chinese medicine. The Commercial Press, Hong Kong
Ying JZ, Mao XL, Ma QM, Zong YC, Wen HA (1987) Icones of medicinal fungi from China. Science Press, Beijing, pp 1–575
Zang M, Kinjo N (1998) Notes on the alpine Cordyceps of China and nearby nations. Mycotaxon 66:215–229
Zhu X (1990) Immunosuppressive effect of cultured Cordyceps sinensis on cellular immune response. Chin J Modern Devs Trad Med 10:485–487
Zhu JS, Halpern GM, Jones K (1998) The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis. J Altern Complement Med 4(3):289–303
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Singh, R., Negi, P.S., Dwivedi, S.K. (2018). Ophiocordyceps sinensis: The Medicinal Caterpillar Mushroom. In: Singh, B., Peter, K. (eds) New Age Herbals. Springer, Singapore. https://doi.org/10.1007/978-981-10-8291-7_6
Download citation
DOI: https://doi.org/10.1007/978-981-10-8291-7_6
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-8290-0
Online ISBN: 978-981-10-8291-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)